Award Data

DESCRIPTION (provided by applicant): Group sequential trials is the term used to describe clinical trials that take place over a period of time, with statistical analyses being conducted at various points over the course the trial. If it can be shown at an interim analysis that the treatment is effective there may be an ethical imperative to stop the study at that point, and for this reason gro ...

DESCRIPTION (provided by applicant): We have developed high-throughput mass spectrometric methods for mapping the structure and the location of active sites of proteins. These methods rely on measuring changes in solvent-accessibility and stability in the presence and absence of a small or large molecule ligands, as determined from the exchange rates of solvent deuterons with amide NH and sidecha ...

DESCRIPTION (provided by applicant): Cardiovascular disease continues to be the leading cause of mortality and morbidity in the United States To assist health care practitioners in their integration of new information into clinical practice, professional organizations such as the National Cholesterol Education Program Expert Treatment Panel (ATP Ill), American Heart Association (AHA), American Col ...

DESCRIPTION (provided by applicant): The overall goal of this research is the design, development and in vivo testing of a biologically active, collagen-based coil for the embolization of cerebral aneurysms. Our research hypothesis for this investigation is that type I collagen-based material will promote and facilitate fibrous tissue formation within the aneurysm cavity and therefore, will sta ...

DESCRIPTION (provided by applicant): The overall goal of this research is the design, development and in vivo testing of a biologically active, collagen-based coil for the embolization of cerebral aneurysms. Our research hypothesis for this investigation is that type I collagen-based material will promote and facilitate fibrous tissue formation within the aneurysm cavity and therefore, will sta ...

DESCRIPTION (provided by applicant): High-content screening (HCS) via high-resolution fluorescence cellular microscopy is a powerful technology for drug discovery and is currently being used in secondary screening and optimization of candidate compounds. The aim of Cytoprint's proposed effort is to demonstrate advanced image analysis informatics tools to address critical bottlenecks in the deploym ...

DESCRIPTION (provided by applicant): We have developed a water-based gel that changes color in response to doses of ionizing radiation, producing a stable, non-diffusing image of the radiation dose distribution. We have also developed an optical scanner system to record and manipulate the three-dimensional images. The system has significant advantages over competing methods. In this Phase I pro ...

DESCRIPTION (provided by applicant): The aim of this program is to develop an instrument suitable for screening the carotid artery for stenoses that lead to stroke. In the last decade it was shown that removal of high grade carotid stenoses could reduce the stroke rate in that population by more than 50%; as strokes caused by such stenoses are associated with 120,000 strokes per year, reducing the ...

DESCRIPTION (provided by applicant): Development of a self-monitoring graft is the long term goal of this project. Such a graft, rather than being a passive conduit for blood, would measure the blood flowing through it and, if the flow approached levels at which the graft might thrombose, communicate the need for treatment directly to the physician. At present, 60,000 artificial by-pass leg gra ...

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