Award Data

THE GOAL OF THIS RESEARCH IS TO DEVELOP AND ADAPT VESTEC CORPORATION'S "UNIVERSAL INTERFACE" TO COUPLE CONVENTIONAL HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) TO ELECTROSPRAY MASS SPECTROMETRY. THE INTERFACE, WHICH HAS BEEN SUCCESSFULLY APPLIED TO COUPLING REVERSED-PHASE HPLC AT FLOW RATES AS HIGH AS 1.5 ML/MIN OF AQUEOUS EFFLUENT TO ELECTRON IMPACT MASS SPECTROMETRY, PRODUCES AN AEROSOL OF DRO ...

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In the last several years there has been an explosion of information regarding the nature of peptide antigens expressed on human tumors together with class I molecules encoded in the Major Histocompatibility Complex (MHC) and recognized by cytotoxic T lymphocytes (CTL). One very successful approach aimed at the identification of these antigens, termed Direct Identification of Relevant Epitopes for ...

Catheters are one of the most commonly used biomaterial implants, (200 million annually in the U.S.). In long term use as for vascular central lines, the urinary tract and peritoneal dialysis, catheters are particularly susceptible to infection. These infections are resistant to antibiotic treatment and persist until removal of the device. Utilizing the concept of Passive Local Immunotherapy, (PL ...

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THIS PROJECT WILL EXAMINE THE NEEDS OF OLDER PERSONS FOR IMPROVEMENTS IN THE INTERFACE DESIGNS OF HAND-HELD CONTROL UNITS FOR REMOTELY CONTROLLING EQUIPMENT AND SOFTWARE, ESPECIALLY TELEROBOTS. THESE REMOTE CONTROL UNITS (RCUS), PROLIFERATING WITHOUT ADEQUATE HUMAN FACTORS ENGINEERING, WILL BE USED INCREASINGLY BY SENIORS IN THEIR HOMES AND AT WORK. THE ONLY STUDY OF RCUS INDICATES THAT THEIR OPER ...

THIS RESEARCH WILL EXPAND UPON PRELIMINARY STUDIES THAT DEMONSTRATED THE FEASIBILITY OF A SOLID-PHASE, FLOW-THROUGH DEVICE TO CARRY OUT CATALYTIC HYDROGEN TRANSFER REACTIONS. THESE STUDIES USED PALLADIUM-COATED GLASS FIBER FILTERS AS WELL AS SILICA/POLYVINYLCHLORIDE MEMBRANE. PHASE I RESEARCH WILL EVALUATE OTHER SUPPORTS, FOR EXAMPLE, CONTROLLED PORE GLASS AND SILICA/POLYETHYLENE MEMBRANES, AS MAT ...

MOTOR OPERATED GATE VALVE OPERABILITY PROBLEMS AND FAILURES AT NUCLEAR POWER PLANTS ARE A MAJOR SAFETY CONCERN AS STATEDIN NRC IE BULLETIN 85-03 AND GENERIC LETTER 89-10. THIS PROPOSAL IS AIMED AT IMPROVING GATE VALVE PERFORMANCE BY (1) DEVELOPING COMPREHENSIVE PERFORMANCE PREDICTION MODELS FOR USE OVER A RANGE OF OPERATING CONDITIONS, (2) DEFINING LIMITS, BASED ON SPECIFIC DESIGNS, BEYOND WHICH E ...

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