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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. BAC Sudoku Sequencing Paradigm to Accelerate Metagenomic Natural Product Chemistr

    SBC: LUCIGEN CORPORATION            Topic: NCCIH

    DESCRIPTION (provided by applicant): There is societal need for new compounds in our arsenal of defenses against microbial pathogens, many of which are increasingly resistant to existing therapeutics. The best possible source for new antimicrobial compounds with potentially novel mechanisms of action is within natural environments, particularly soils, which have the greatest diversity of microbial ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Development of SFS Fractionators

    SBC: APHIOS CORPORATION            Topic: NCCIH

    DESCRIPTION (provided by applicant): The screening of a complex mixture of analytes is not always successful in sensitive screens for specific activities. Often, specific activities are masked by interfering compounds or false positives are given by ubiquitous compounds that interact with all screens. This problem can be resolved by purification of the analytes. Such an approach is not only cost-p ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Increased bioavailability of polyphenols through bacterial metabolism

    SBC: AGRO BIOSCIENCES, INC.            Topic: NCCIH

    DESCRIPTION (provided by applicant): Numerous preclinical studies have demonstrated multiple health benefits including anti- inflammatory, antioxidant, and chemopreventive effects of dietary polyphenols. These compounds are abundant in plants and have added to the health benefits of many fruits, such as raspberries, pomegranates, and strawberries. As aging population in the U.S. and other develope ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Real-time assessment of surgical margins with enhanced contract optical imaging

    SBC: Physical Sciences Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with Massachusetts General Hospital proposes to investigate the use of a high sensitivity/specificity cancer targeting agent and of a novel fluorescence-guided microscopy(FGM) scheme for intraoperative assessment of surgical margins in breast cancer patients. The contrast agent will be used to label cancer cells a ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Chemical optimization of a novel class of USP7 inhibitor for cancer treatment

    SBC: Progenra, Inc            Topic: NCI

    DESCRIPTION (provided by applicant): Many regulatory proteins are themselves tightly controlled by ubiquitin conjugating and deconjugating enzymes, whose dysfunctional forms are implicated in numerous diseases, including cancers. USP7, a deubiquitylating enzyme, regulates ubiquitylation and, thereby, stability of the E3 ligase HDM2, which in cells effects ubiquitylation and promotes proteasomal de ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Ubiquitin based therapy of aggressive cancer cell populations

    SBC: Progenra, Inc            Topic: NCI

    DESCRIPTION (provided by applicant): The degradation of most cellular proteins is regulated by coordinated addition and removal of ubiquitin by families of ubiquitin E3 ligases and deubiquitylating enzymes (DUBs) respectively. DUBs proteolytically cleave ubiquitin molecules from proteins resulting in modifications of protein activity, localization and function. Several DUBs are aberrantly regulate ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Optimization of bifunctional pharmacophores for the treatment of neuroblastoma.

    SBC: HARO PHARMACEUTICAL, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Genetic alterations that maintain cells in a poorly differentiated state are a hallmark of many leukemia and childhood cancers. Among them, neural crest-derived neuroblastoma is the most prevalent cancer in infants andthe most common extracranial solid tumor in children with the majority of patients being 5 years old or younger. Approximately 650 neuroblastoma ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. A Novel Antibody Drug Conjugate for Metastatic Renal Cancer Treatment

    SBC: CENTROSE LLC            Topic: NCI

    Project Summary The incidence of renal cell cancer has been rising steadily and for those that have tumor recurrence after surgery, the prognosis is generally poor. In 2013 an estimated 65,150 new cases and 13,680 deaths will be attributed to renal cancerin the United States. Renal cancer is the most common malignancy of the adult kidney and accounts for 2-3% of all adult malignancies. Of these, 3 ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. A Potent Small Molecule Chemokine Antagonist Blocks Tumor Cell Dissemination In V

    SBC: ALLIANCE DISCOVERY INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Evidence in pre-clinical and clinical settings suggests the involvement of chemokines in metastatic tumor cell disease spreading. We have recently provided data validating the involvement of the CX3CR1/Fractalkine axisin breast and prostate cancer metastasis. We have discovered a potent in vivo efficacious drug-like small molecule using in vitro chemotaxis and ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Expression System and Process Development for MIS Scale Up

    SBC: NEMUCORE MEDICAL INNOVATIONS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Ovarian cancer is a highly lethal gynecologic cancer with an estimated 21,860 new cases and approximately 13,850 deaths in the USA per year. A large majority of the patients, cancer reoccurs after initial treatment and manifest resistance to conventional and novel chemotherapeutic agents representing a formidable clinical challenge, which could be mitigated b ...

    SBIR Phase I 2014 Department of Health and Human Services

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