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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development and Utilization of a Novel Aerosol-Generating Technology to Deliver Luc

    SBC: DISCOVERY LABORATORIES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Respiratory distress syndrome (RDS) is an acute, severe pulmonary disorder that is the leading cause of morbidity and mortality in preterm infants. It is a major healthcare concern - costs associated with treatment of RDS and its complications exceed 2.4 billion annually in the US. Currently, animal-derived surfactants instilled intratracheally via an endotrac ...

    SBIR Phase II 2014 Department of Health and Human Services
  2. Infection resistant surface for ventricular assist device (VAD) transcutaneous dr

    SBC: ENSION Inc            Topic: NHLBI

    DESCRIPTION (provided by applicant): Infection is a common and frequently very serious complication associated with medical implants. Man-made materials, including those used to fabricate ventricular assist devices (VADs), compromise the body's ability tofight infection in tw ways. First, by breaching skin with transcutaneous cannulae and drivelines, and second, by eliciting a foreign body re ...

    SBIR Phase II 2014 Department of Health and Human Services
  3. An Early-Phase Clinical Trial Evaluating ABC294640 in Patients with Refractory/Re

    SBC: Apogee Biotechnology Corporation            Topic: 102

    DESCRIPTION provided by applicant Diffuse large B cell lymphoma DLBCL represents one of the most common variants of Non Hodgkinandapos s lymphoma NHL and oncogenic herpesviruses EBV and KSHV are the etiologic agents for the majority of these tumors in patients over or those infected with the human immunodeficiency virus HIV Despite modest improvements in outcomes for patients rece ...

    STTR Phase II 2014 Department of Health and Human Services
  4. Developing Intravesical Liposomes for Interstitial Cystitis

    SBC: LIPELLA PHARMACEUTICALS, INC.            Topic: NIDDK

    DESCRIPTION provided by applicant Lipella Pharmaceuticals Inc Pittsburgh PA is a clinical stage pharmaceutical company specializing in intravesical therapies for urinary bladder dysfunctions Lipella is submitting a research proposal to the Small Business Technology Transfer program titled andquot Developing Intravesical Liposomes for Interstitial Cystitisandquot The project proposes to e ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Broad-spectrum, orally-bioavailable beta-lactamase inhibitors

    SBC: VenatoRx Pharmaceuticals, Inc.            Topic: R

    DESCRIPTION provided by applicant Broad spectrum orally bioavailable lactam antibiotics play a critical role in the management of human infectious diseases both in the hospital and community settings facilitating exit from the ICU and treatment in the general ward early discharge and or prevention of hospitalization The rapid spread of lactamase driven resistance in Enterobacteriaceae ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. TN-LAMP-vax: a Multi-Valent Tree Nut Allergy Immunotherapy

    SBC: Immunomic Therapeutics, Inc.            Topic: R

    DESCRIPTION provided by applicant Extreme reactions to food results in over incidents of anaphylaxis and between deaths in the US each year Allergies to tree nuts TN such as almond cashew hazelnut and walnut are collectively the second most common triggers of anaphylaxis behind peanut An estimated million Americans are allergic to TNs with many impacted by exposure to ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Ocular Formulation Development of Innovative Novel Compounds with superior ocular

    SBC: CATALYST, LLC            Topic: N

    DESCRIPTION provided by applicant As anyone who has had an eye injury or even a small foreign object in the eye knows the cornea and surrounding structures are exquisitely sensitive to physical trauma Ocular pain can be agonizing paralyzing and extremely distressing to both the affected person and particularly in the case of pediatric cases family members who may feel powerless to help S ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Evaluating Photogenotoxicity using 3D Tissue Models

    SBC: MB RESEARCH LABORATORIES, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant The objective of this proposal is to focus on evaluating materials for their ability to cause photogenotoxicity Photosensitivity is a harmful reaction that occurs when drugs or chemicals in the skin or eyes cause undesirable cellular damage when exposed to UV or visible light Photogenotoxicity is used as a means to screen a material for its photocarcinoge ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Enabling technologies for rapid and low cost molecular diagnosticshttps://apps.era.nih.gov/grantfolder/grantfolder/viewGrantFolder.do?businessAreaCode=GM&applID=8930749&folderID=90

    SBC: Atharva LLC (dba Atharva Sciences)            Topic: 172

    DESCRIPTION provided by applicant Molecular techniques including diagnostics that require separation or identification of different sized nucleic acid sequences have remained unchanged over the last several decades and rely primarily on some form of electrophoresis Diagnostics for several human diseases such as those associated with trinucleotide repeat instability exemplified by Fragile X s ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Developing a Point-of-Care Device for the Diagnosis of Sickle Cell Disease in Low Resource Settings

    SBC: ROCKLAND IMMUNOCHEMICALS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Hemoglobinopathies are the most common monogenic diseases with approximately of the worldandapos s population being carriers Sickle cell disease SCD and thalassemia are primarily hemoglobin disorders The current SCD diagnostic methods require expensive equipment and are performed by highly trained laboratory technologists Presently there are no simple ...

    SBIR Phase I 2014 Department of Health and Human Services

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