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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. HLS Cyclic CAR peptide a targeted therapy for pulmonary hypertension

    SBC: VASCULAR BIOSCIENCES            Topic: NHLBI

    PUBLIC ABSTRACT This project in response to announcement HLS describes a development program for CARSKNKDC CAR a synthetic cyclic peptide that selectively targets diseased pulmonary vascular endothelium and enhances the therapeutic effect of vasodilator therapies for the treatment of pulmonary hypertension PH PH is a disorder of elevated pulmonary vascular resistance characterized by ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Tuned stem cell extracellular vesicles as a novel chronic wound therapeutic

    SBC: ZEN-BIO, INC.            Topic: NIA

    Project Summary The elderly population is rapidly increasing worldwide and those over years old are expected to comprise of the total population by These demographic changes will focus healthcare needs on those conditions more prevalent in the elderly Chronic wounds such as venous leg ulcers pressure ulcers and diabetic ulcers are over represented in the elderly population and even ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. HLS Detection of RNA biomarkers in individual platelets

    SBC: Blood Cell Technologies LLC            Topic: NIA

    Name of Applicant Last First Middle GNATENKO Dmitri V ABSTRACT This SBIR Phase I application is submitted in response to Small Business Topics of Special Interest TOSI initiative HLS The overall goal of the proposal is to develop and commercialize an assay for detection of RNA biomarkers in circulating blood platelets developed as a novel diagnostic approach with potential applicab ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Evaluation of a therapeutic strategy to combat osteoarthritis

    SBC: biOOrg3.14 LLC            Topic: NIA

    ABSTRACT Osteoarthritis OA affects over million US adults it is one of the most common chronic health conditions and a leading cause of pain and disability among adults OA is a degenerative disease of the articular joints characterized by focal areas of cartilage fibrillation articular cartilage hypertrophy bon changes and eventual destruction of the articular surface Current FDA approv ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. BurntOut Role Play Simulation for Building Medical Student Resiliency

    SBC: Clinical Tools, Inc            Topic: 400

    We propose to produce a simulation experience to ensure that clinical year medical students are prepared for have coping strategies to deal with and are more resilient to the stresses and challenges that await them as they transition to clinical practice and learning in a clinical environment The experience will guide institutional level change by anonymously communicating studentsandapos conc ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Development of an Alzheimer s disease specific antibody biomarker for a tau oligomer fragment

    SBC: Oligomerix, Inc.            Topic: NIA

    PROJECT SUMMARY Phase I SBIR PA Title Development of an Alzheimer s disease specific antibody biomarker for a tau oligomer fragment The prevalence of Alzheimer s disease AD is increasing worldwide due to demographic shifts and an aging population and currently there are no disease modifying drugs It is the most costly disease in the US with a financial burden of over $ billion a ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A neurokinin receptor agonist to treat underactive bladder in the elderly

    SBC: Dignify Therapeutics LLC            Topic: NIA

    PROJECT SUMMARY ABSTRACT Underactive bladder UAB is a condition wherein a bladder contraction of reduced strength and or duration results in prolonged bladder emptying and or a failure to achieve complete bladder emptying within a normal time span The overarching hypothesis of this application is that in the absence of physiologically induced bladder contractions pharmacologically induced co ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. FrostBite BC A New Thermal Ablation Device for Treating Bladder Cancer

    SBC: CELL PRESERVATION SERVICES INC            Topic: 102

    The need for the development of new strategies for treatment of bladder cancer BC has experienced a palpable increase in the last few years While several options are currently under investigation many if not all remain suboptimal This is critical as it is estimated that in there were new cases and over deaths from BC worldwide In the US alone there were new case ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Engineering Hair Follicles in Vascularized D Skin Models

    SBC: Rapunzel Bioscience, Inc.            Topic: NIAMS

    ABSTRACT Each year more than one million patients are hospitalized in the U S for significant skin loss due to thermal and pressure injuries chronic diabetic ulcers or genetic skin diseases The ability to generate engineered human skin equivalents HSEs has provided a promising and effective therapy for these patients However currently available HSEs still have various limitations including ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A D osteoarthritis model targeting patient populations with high risk genetic polymorphisms

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    Abstract Osteoarthritis OA is a degenerative joint disease that affects an estimated million adults in the United States and results in an economic burden of over $ billion per year Although the burden of OA is immense current non surgical treatments are only palliative and no disease modifying OA drugs DMOADs presently exist to address the problem This lack of success in identifying ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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