Award Data

A CENTRAL ELEMENT IN MILITARY EXPERT-SYSTEM (ES) APPLICATION IS THE DYNAMIC HANDLING AND ADAPTIVE CONTROL OF EVIDENCE AND UNCERTAINTY. THERE ARE CURRENTLY FIVE DISTINCT APPROACHES TO THE PROBLEM OF EVIDENTIAL REASONING (ER). THESE ARE THE BAYESIAN, NEYMAN-PEARSON, DEMPSTER-SHAFTER, KYBURG, AND POSSIBILITY/FUZZY APPROACHES. IN ADDITION TO THE ER TASK OF REVISING DEGREES OF BELIEF OR SUPPORT, WE MUS ...

WE HAVE DESIGNED A NOVEL WOUND DRESSING MATERIAL WHICH IS NONADHESIVE,BACTERICIDAL, BIOLOGICALLY COMPATIBLE (NONIMMUNOGENIC, NONINFLAMMATORY, NONTHROMBOGENIC) AND IMPERMEABLE TO BACTERIA. WOUND DRESSING MATERIALS IN USE TODAY (EXAMPLE: GAUZE) CAN BE TREATED WITH AN INSOLUBLE, ANTIBIOTIC-CONTAINING, HYALURONIC ACID (HA) COATING TO PROVIDE A PERMEABLE, NONADHESIVE (CLOTTED BLOOD-WET OR DRYWILL NOT B ...

CRYOGENIC HELIUM REFRIGERATORS AND LIQUIFIERS CONVENTIONALLYEMPLOY OIL LUBRICATED POSITIVE DISPLACEMENT COMPRESSORS AT THE WARM END AND FREQUENTLY USE PISTON TYPE EXPANSION ENGINES AT THE COLD END. THESE SYSTEMS REQUIRE EXTENSIVE AND VIGILANT MAINTENANCE TO CONTROL CONTAMINATION FROM LUBRICATING OIL AND ITS VOLATILE COMPONENTS MIGRATING TO THE COLD END. HENCE THE NEED FOR LOW MAINTENANCE COMPRESSO ...

Project Summary AbstractThe goal of this work is to develop a therapeutic drug that will protect individuals with celiac diseaseCDfrom intestinal and symptomatic distress they suffer due to minute ingestion of gluten proteinCD is an autoimmune disorder affecting the small intestineafflicting aboutof the world s populationfor which there is no known cureCurrently the only therapeutic option to avoi ...

Project Summary The goal of this work is to evaluate the efficacy of a therapeutic agent for protecting individuals with TypediabetesT Dand celiac diseaseCDfrom intestinal and symptomatic distress they suffer due to minute ingestion of gluten proteinBoth T D and CD are lifelong autoimmune diseases whose management is anchored upon very restrictive and distinct dietsThe co morbidity of these two di ...

ABSTRACT Neurodegenerative disordersincluding amyotrophic lateral sclerosisALSFriedreichandapos s ataxiaFAmultiple sclerosisMSDuchenne muscular dystrophyDMDAlzheimer s diseaseADParkinson s diseasePDand Huntington s diseaseHDare characterized by heterogeneous disease progressionEfforts to identify responder subgroups may uncover subgroups that are more homogeneous in disease related features than t ...

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ABSTRACT ZATA PharmaceuticalsIncWorcesterMAand NYBCNew YorkNYpropose to develop a closeddisposable pathogen reduction systemZ Systemfor treatment of packed Red Blood CellspRBCfor transfusionThe versatility of the proposed technology allows for several versions of the Z Systems to be createdadapted to different regulatory environmentsand for treatment of whole blood and any of its componentsHowever ...

Rapid increase in observational data, brought about by the development and availability of Internet-of-Thing devices and measurement technological advancements, is posing a Big Data challenge for many domains of science and engineering, both research and commercial. These types of Big Data, however, are fundamentally different from the Big Data that exist in the business intelligence community alt ...

Project Summary Abstract Covalent drug discovery is gaining increasing interest and clinical successespecially for cancer and infectious diseasesAlthough old covalent drugs were discovered serendipitouslymodern covalent drug discovery takes a rational approachWhile chemical intuition and trial and error are helpfulthe discovery process can be signi cantly shortened by the knowledge of whether the ...