Award Data

PROJECT SUMMARY/ABSTRACT Latino adolescents with Type 1 Diabetes (T1D) face substantial disparities in care and outcomes, making new tools to support this population essential. Managing T1D requires a complex set of knowledge and decision- making skills. Adolescents have specific challenges to managing T1D, including psychosocial needs for autonomy and fitting in with peers, along with still-devel ...

PROJECT SUMMARY / ABSTRACT Title: Accelerating Gene Therapy and Editing with Advanced MS-Based Data Analysis for Nonstandard and Hybrid Nucleotide Sequences This project seeks to improve reliability and speed up the development of life-saving and life-enhancing oligonucleotide-based therapeutics and magnify the positive impact of biomedical research and education worldwide, leading to a quantum le ...

Project Summary/Abstract Unexpected adverse drug responses (ADRs) including drug-induced liver injury (DILI) are the 4th leading cause of death in the U.S. In addition, DILI in individuals is one of the major reasons for drug withdrawal from the market and is difficult to predict using conventional in vitro hepatotoxicity tests and preclinical animal models. Due to the critical link between DILI a ...

SUMMARY The use of platelet transfusions has increased dramatically since 1980s, but a safe, long-term platelet storage method remains missing. Current practice has platelets stored at 20 to 24°C after preparation, which has a limited lifetime up to 5 days primarily due to concerns about bacterial contamination, because cold storage of platelets results in complex molecular lesions that are recog ...

AbstractThe objective of this project is to further develop a breakthrough Toehold-Enrichment- Extraction (TEE) technology and validate TEE-based tests for use in cancer detection and care management. TEE is a novel DNA extraction method. Unlike conventional extraction methods, TEE extracts mutated DNA while enriching it with high recovery. Moreover, unlike current PCR- based enrichment methods, T ...

AbstractThe ultimate goal of this project is to develop and commercialize peptide drug conjugates to treat life- threatening triple negative breast cancer. Triple negative breast cancer (TNBC) is a high aggressive subtype of breast cancer with poor survival. TNBC patients do not respond well to currently available clinical therapies, including targeted therapy. Chemotherapy is commonly used to tre ...

PROJECT ABSTRACT: The goal of this Phase II SBIR proposal is to further validate the genetically defined Oncopig hepatocellular carcinoma (HCC) model—capable of modeling diverse HCC driver mutational profiles through induced KRASG12D and TP53R167H expression and subsequent CRISPR editing—for preclinical evaluation of locally delivered, personalized HCC therapies. HCC is an aggressive liver mal ...

Summary Tears of the anterior cruciate ligament (ACL) lead to instability of the knee and reduce mobility. An estimated 225,000 ACL tears are reported annually in the US, equating to ~$7B in medical costs. The preferred treatment is reconstruction of the patient’s ACL with an autograft or allograft, which can cause donor site morbidity or immunological response, and have an increased risk of chr ...

The key to tracking, collating, and communicating skin cancer data is standardization, enhanced precision, and categorization of anatomic descriptions. Imprecise and non-standardized labeling of anatomic sites for skin cancer biopsies creates challenges in communicating and identifying the skin cancer location at the time of treatment. Diagnostic biopsies often remove the visible cancer cells, and ...

1 Summary:2 There are ~300,000 rotator cuff (RC) repair procedures performed in the US annually at an estimated cost of3 $4B. Advanced degeneration of the RC causes pain and major disability. ‘Massive’ or ‘Irreparable’ (rt 5 cm) tears4 of RC consist of detachment between bone and tendon, and degeneration of tendon; thus, they cannot be repaired5 arthroscopically. Representing 40% of RC tea ...