Award Data

Nano Terra, Inc. and the Harvard Stem Cell Institute propose to develop a novel nerve grafting system that will support intrinsic neuronal repair (injuries 3 cm). The creation of an implantable device or devices utilizing a novel scaffold provides an opportunity to utilize a biocompatible material that can easily be manufactured to desired structural and mechanical specifications, i.e., fiber diam ...

The overall objective of this program is to develop a practical process for the production of large crystals of BaTiO3, PZT, or other commercially interesting material via solid phase consolidation of nanoscale powders. To accomplish this goal three key challenges were addressed: 1) a facile synthetic procedure for generating micron-scale seed crystals, 2) a process for patterning seed crystals wi ...

DESCRIPTION provided by applicant Decreasing readmissions through better discharge planning DP and transitional care is a national healthcare priority RightCare Solutions has leveraged over years of interdisciplinary academic research led by a nurse researcher and through our highly successful phase one SBIR grant demonstrated market value for the D S product and the technical expertise ...

In this Phase II program Polestar Technologies Inc. will fabricate a prototype system based on the principles demonstrated in Phase I and demonstrate its capability for specific and sensitive detection of both the 9-aminoacid and the 12-aminoacid forms of Oxytocin. During Year 1 of our Phase II program, a first generation prototype will be fabricated and optimized for all the three steps involved. ...

DESCRIPTION provided by applicant Monoclonal antibodies mAbs have become the leading drug class for cancer treatment and over anti neoplastic mAbs are in the biopharmaceutical pipeline Most mAb therapies must be administered in doses of mg kg resulting in per patient costs of up to $ per year The high price of mAb therapy causes a significant financial burden for patients ...

DESCRIPTION provided by applicant In this NIH SBIR Phase II Actuated Medical Inc will finalize and clinically test the andquot Active Fine Gauge Spinal Needle with CSF Sensing to Minimize PDPH and Dura Damage andquot Phase I achieved all Specific Aims and demonstrated that the Smooth Insertion Spinal SIS System provided greater control for the clinician by reducing the buckling of G tra ...

A probabilistic programming/modeling language will be developed and maintained as an open source project. A broad based open source community will be cultivated to support, extend, and manage the core language. A compilation system that has knowledge of certain machine learning algorithms will be developed as a compilation back end system.

DESCRIPTION provided by applicant Identification quantification and isolation of low abundance proteins from complex mixtures is at best a difficult task This is especially the case for proteins carrying a post translational modification PTM that affects their half life or regulatory properties Examples of such PTMs include phosphorylation glycosylation especially O GlcNAcylation an ...

DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

Electromagnetic fields high enough to damage RF receivers and other electronic hardware are a threat that is becoming more likely to be encountered. PSIs results in Phase I of this SBIR program included: Demonstration of modulator survival to >1000 V; Demonstration of modulator survival up to 1 kW pulse at 10 GHz; Measured recovery time of ~2.5 ms after current pulses and microwave pulses at power ...