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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 51 - 60 of 173966 results
  1. Commercialization of an Ultrasound-guided Vascular Access Device

    SBC: PERCEPTIVE NAVIGATION LLC            Topic: NHLBI

    PROJECT SUMMARY Safe and reliable access to major blood vessels and internal organs will be beneficial to patients with cardiovascular and cardiothoracic diseasesAn interventional catheter with forward viewing ultrasound imaging capability will be developed to enable image guided access to blood vessels and internal organsPhaseandexperiments demonstrate feasibility of building a high resolutionfor ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Development of a novel therapeutic for the treatment of diabetic nephropathy and renal fibrosis

    SBC: Epigen Biosciences, Inc.            Topic: 400

    SummaryThe ultimate goal of our project is to develop novel therapeutics effective in chronic kidney diseasessuch as diabetic nephropathyDNthat normally develop fibrosislead to end stage renal disease and require renal replacement therapyDN is a complication of diabetes and is characterized by thickening of the glomerular basement membrane and mesangial expansionwith progression into glomeruloscle ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Validation of a Novel Fungicidal Approach for Cryptococcal Meningitis

    SBC: Minnetronix Medical, Inc.            Topic: NIAID

    ABSTRACT When Cryptococcus is manifested as cryptococcal meningitisCMit creates a large burden of mortality and morbidity to the patient and is very difficult for the clinician to treatThere are now an estimatedUS cases andcases of CM worldwide annuallywith estimated mortality ofper yearCM is caused when Cryptococcus neoformansa basidiomycete fungal pathogeninvades the central nervous systemCNSIt ...

    STTR Phase II 2018 Department of Health and Human Services
  4. Development of CB1 Monoclonal Antibodies for Treating NASH

    SBC: INTEGRAL MOLECULAR, INC            Topic: 300

    ABSTRACT Nonalcoholic fatty liver diseaseNAFLDis the accumulation of intra hepatic lipids within hepatocellular lipid dropletsorhepatic steatosisHepatic steatosis can progress to nonalcoholic steatohepatitisNASHa chronic inflammatory condition that can lead to liver fibrosis and cirrhosisUnderlying factors associated with the development of NAFLD NASH include obesity and hyperlipidemiaNASH current ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Novel Methodology for Identification of Senolytics that Reduce Age-related Disease and Dysfunction

    SBC: Recursion Pharmaceuticals, LLC            Topic: NIA

    DESCRIPTIONprovided by applicantChronic diseases of aging account for a significant proportion of healthcare spending and result in a painful and limiting existence for many tens of millions of Americans and hundreds of millions of people around the worldRecursion Pharmaceuticals has developed a drug discovery platform that re purposes known drugs for the treatment of such diseasesThe platform con ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Plasmid DNA positive control standards for molecular environmental assays

    SBC: Pisces Molecular LLC            Topic: 843

    TECHNICAL ABSTRACT: We believe that employing current molecular biology techniques it is possible to develop plasmid DNA based positive control standard kits for a wide variety molecular assays for environmental organisms, and that this represents a significant commercial opportunity. In Phase I we demonstrated that plasmid DNA-based qPCR positive controls are stable, perform as well as genomic DN ...

    SBIR Phase II 2018 National Oceanic and Atmospheric AdministrationDepartment of Commerce
  7. Space weather-based position error maps for TEC- OnLine (SpoT-On)

    SBC: Space Environment Technologies            Topic: 831

    TECHNICAL ABSTRACT: The Space weather-based Position error maps for TEC - On-line (SpoT-On) project will use GPS-GNSS based TEC data, integrated into the Global Assimilation of Ionospheric Measurements (GAIM) operational system at the Utah State University Space Weather Center to produce an order of magnitude improved TEC position correction maps. These will be publicly and globally accessible. A ...

    SBIR Phase II 2018 National Oceanic and Atmospheric AdministrationDepartment of Commerce
  8. Open Water- A Citizen Science Monitoring Platform

    SBC: CREARE LLC            Topic: 833

    TECHNICAL ABSTRACT: Ensuring the health of coastal marine ecosystems has emerged as one of the primary environmental concerns of this century. Frequent monitoring of water quality is required to establish baseline levels and enable early detection of problems. Citizen science programs have been shown to provide a highly effective method of monitoring water quality. Creare is developing an open-sou ...

    SBIR Phase II 2018 National Oceanic and Atmospheric AdministrationDepartment of Commerce
  9. A Compact and Agile Fixed-Wing UAS for VTOL Shipboard Operations

    SBC: CREARE LLC            Topic: 832

    TECHNICAL ABSTRACT: Commercially available unmanned aircraft systems (UASs) are not well designed to meet requirements for many atmospheric measurement applications, including deployment from ships, long endurance, and low cost. Existing multi-rotor systems suffer from limited payload and endurance. Existing fixed wing systems offer improved endurance and payload, but require significant support h ...

    SBIR Phase II 2018 National Oceanic and Atmospheric AdministrationDepartment of Commerce
  10. Manual and Automated Marine Weather Observations Using Smartphones

    SBC: CREARE LLC            Topic: 826

    TECHNICAL ABSTRACT: Accurate marine weather nowcasts and forecasts are critical requirements for mariners to maintain situational awareness and ensure safe navigation for vessels, passengers, crew, and cargo. To best achieve this, reliable observations of atmospheric and sea conditions must be available at high spatial and temporal coverage. Unfortunately, existing approaches for marine weather ob ...

    SBIR Phase II 2018 National Oceanic and Atmospheric AdministrationDepartment of Commerce

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