Award Data

This project will result in a catheter and associated instrumentation that will use measurements ofof coronary arteries caused by atherosclerotic lesions to diagnose and characterize those lesions. Tinserted into the coronary arteries to a location proximal to the lesion. It will generate low-press1 and 50 kHz to diagnose the lesion. The change in the compliance or distensibility, of the vessel nw ...

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Catheters are one of the most commonly used biomaterial implants, (200 million annually in the U.S.). In long term use as for vascular central lines, the urinary tract and peritoneal dialysis, catheters are particularly susceptible to infection. These infections are resistant to antibiotic treatment and persist until removal of the device. Utilizing the concept of Passive Local Immunotherapy, (PL ...

Although prostate cancer is the most common malignancy among males in the U.S, little is known abougenes involved in prostate carcinogenesis. Cytogenetic and restriction fragment polymorphism data haof 10q in as many as 30% of prostate cancers. In a collaborative effort with a prostate cancer laborEdward Gelmann (Georgetown Univ.), we have shown that the microsatellite marker D10S187 in 10q25 exhh ...

Human chromosome 10Q24 contains a putative tumor suppressor gene whose inactivation is responsibledevelopment of prostate cancer. The overall goal of this research project is to isolate transcribedchromosomal region to identify candidates for this tumor suppressor gene. Two approaches will be useterminal exon trapping and direct cDNA selection. Both approaches will be applied to large genomic fyea ...

We will develop methods that will permit the application of genomic mismatch scanning (GMS) to thegenome. If GMS can be applied to humans, it will rapidly identify the sub-chromosomal locations of cdisorders, such as non-insulin dependent diabetes mellitus, facilitating the subsequent isolation ofuse resources that are currently in house including a hybrid cell line, a set of yeast artificial chDN ...

The objective of the proposed work is to perform feasibility studies leading to the development of a novel, new detector for scintigraphy mammography capable of improving the diagnosis of breast cancer and lowering the number of false-positive diagnoses leading to unnecessary invasive biopsies, thereby reducing trauma to the patient while at the same time saving billions of dollars in the national ...

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