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PROJECT ABSTRACT The long term goal of this project is to optimize a protein therapeutic for Duchenne muscular dystrophyDMDand potentially other muscle diseasesthat will enhance the repair capacity of muscle cell membranes that are compromised by mutations in the dystrophin dystroglycan complexMutations in the dystrophin dystroglycan complex result in Duchenne muscular dystrophyMyos Incis developi ...

PROJECT SUMMARYThree of top five causes of death in humans globally are lung relatedchronic obstructive pulmonary diseaseCOPDlower respiratory infections and lung cancers collectively account for over eight million deaths annuallyCurrentlyin preclinical settingstatic cell cultures and animal models are the most widely used systems for mechanistic and translational studiesHowevercritical limitation ...

Falls are a significant source of early morbidity and mortality in the aging population, yet the neurological,sensory, and motor changes that lead to increased fall risk often escape early identification and intervention. Vital signs are commonly used in clinical settings to assess the cardiovascular system (blood pressure, heart rate), immune system (body temperature), and the respiratory system ...

Defense against chemical weapons is a critical DoD requirement. An effective defense requires the development of unique respirator systems that prevent inhalation of chemical warfare (CW) agents. In addition, the protective equipment exposed to CW agents must not pose a residual hazard after use in the battlefield. Existing respirator canisters remove CW agents, but they do not self-decontaminate ...

Distributed Spacecraft Missions (DSM) architectures provide unique scientific and programmatic benefits including multipoint in-situ measurements, multi-angle viewpoints, and improved understanding of the connections between separately measured phenomena and their time variations. However, these missions impose significant operational demands on ground tracking resources and mission operators alik ...

Atomic structures of biomolecules (e.g., proteins) and biomolecular complexes facilitate detailed understanding of biomolecular function. They are key drivers of the ongoing revolution in molecular biology and of many areas of biotechnology, including development of pharmaceuticals and of enzymes and light harvesters for bioenergy. Most biomolecular structures are determined by X-ray crystallograp ...

This project will provide state-of-the-art predictive capabilities for simulating systems central to advancing the U.S. Army’s modernization priorities related to long-range precision fires and future vertical lift platforms. The goals of the project are to: (1) Produce geometry and meshing technologies that support the modeling and discretization techniques needed to explicitly track evolving/i ...

AbstractIf there were a simple and accurate means totake the pulseof a toothi efunctionally similar to a pulse oximeter that could be clipped on a tooth rather than the tip of a fingerthe quality and cost of dental care would be significantly improvedThe ability to measure dental pulp blood flow provides the most direct means to determine the viability of a tooth and is a vital piece of informatio ...

The team of AlphaMicron Inc. and Kent State University proposes a novel LC technology, the dynamic polarizer, as a light control system for Battlefield Airmen and Pilots. The dynamic polarizer technology shares the performance capabilities of AlphaMicron’s e-Tint LC light control technology: instantaneously fails-to-clear, millisecond switching times, and customizable tint and color. Howeve ...

The Intelligence, Surveillance and Reconnaissance (ISR) analysts have a challenging task to extract useful information from huge volumes of data from various sources like Full Motion Video (FMV), Wide Area Motion Imagery (WAMI), satellite imagery, Synthetic Aperture Radar (SAR), and others. Modern Machine Learning (ML) algorithms based on deep learning have greatly advanced computer vision, speech ...