Award Data

PROJECT ABSTRACT The long term goal of this project is to optimize a protein therapeutic for Duchenne muscular dystrophyDMDand potentially other muscle diseasesthat will enhance the repair capacity of muscle cell membranes that are compromised by mutations in the dystrophin dystroglycan complexMutations in the dystrophin dystroglycan complex result in Duchenne muscular dystrophyMyos Incis developi ...

PROJECT SUMMARYThree of top five causes of death in humans globally are lung relatedchronic obstructive pulmonary diseaseCOPDlower respiratory infections and lung cancers collectively account for over eight million deaths annuallyCurrentlyin preclinical settingstatic cell cultures and animal models are the most widely used systems for mechanistic and translational studiesHowevercritical limitation ...

DESCRIPTION (provided by applicant): Wide varieties of peripheral neuropathies accompanied by severe chronic pain are among the most common and debilitating human afflictions. Existing treatments have little long term benefits and often have severe side effects. Increasing evidence indicates that pathologies in the structure and chemistry of the skin and its innervation are likely contributors to ...

Falls are a significant source of early morbidity and mortality in the aging population, yet the neurological,sensory, and motor changes that lead to increased fall risk often escape early identification and intervention. Vital signs are commonly used in clinical settings to assess the cardiovascular system (blood pressure, heart rate), immune system (body temperature), and the respiratory system ...

Electromagnetic launchers or rail guns are a key component of the Navy’s all-electric ship of the future, but they lack the durability required for repeated firings. TDA Research and the University of Nevada, Reno (UNR) are developing a tough, durable and conductive refractory metal coating that will protect the copper alloy conductors (rails) from the extreme heat and wear conditions inside the ...

A spacecraft thermal control system must keep the vehicle, avionics and atmosphere (if crewed) within a defined temperature range. Since water is non-toxic and good for heat transport, it is typically used as the coolant that circulates within the crew cabin boundary. This loop then interfaces with another low freeze point fluid, such as ammonia, for transport of heat to a radiator where the tempe ...

Approximately 5-6% of military injuries involve some form of major peripheral nerve injury with little chance of spontaneous healing. Currently these injuries lead to major impairment of voluntary muscle function in the limbs and extremities, making tasks of walking, reaching, grasping, etc. very difficult or impossible for many patients. It is not enough to focus therapeutic treatment on the se ...

Decontamination of chemical and biological threats demands a very reactive solution. It is ideal to generate the decontaminants on-site: the activated decontaminant is highly reactive and quickly destroys chemical and biological warfare agents; prior to activation the ingredients can be safely stored for years, shipped, and handled. TDA's electrochemical decontamination (eClO2) technology u ...

Defense against chemical weapons is a critical DoD requirement. An effective defense requires the development of unique respirator systems that prevent inhalation of chemical warfare (CW) agents. In addition, the protective equipment exposed to CW agents must not pose a residual hazard after use in the battlefield. Existing respirator canisters remove CW agents, but they do not self-decontaminate ...

This Phase I program is focused on enhancement of the performance of MgZnO based solar blind detectors. MgZnO alloys have superior optoelectronic properties with bandgaps suitable for solar blind detection. Issues related to doping and miscibility will be addressed. This will involve the use of advanced MOCVD and MBE growth techniques and consideration of both Schottky and p-n junction devices. No ...