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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. CONTROLLING THERMAL LESION VOLUME WITH AN OPTICAL PROBE

    SBC: RARE EARTH MEDICAL, INC.            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
  2. Low Cost, Mechanically Driven Mr Compatible Syringe Pump

    SBC: Redington Medical            Topic: N/A

    This project seeks to develop a simple, MR compatible, mechanical infusion pump that employs a consnon-magnetic spring to squeeze a syringe. Contrast medium infusion rate is determined by the springcontrast viscosity, and the resistance of either a small calibre needle or precision orifice accordiBernoulli Effect. Sequential saline flush is provided by a customized tubing set with a standard ivopt ...

    SBIR Phase I 1995 Department of Health and Human Services
  3. NEW NEBULIZER FOR IMPROVED AEROSOL DELIVERY

    SBC: Reid Laboratories            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
  4. GENERATION OF PF4 POLYETHYLENE GLYCOL CONJUGATES

    SBC: REPLIGEN CORPORATION            Topic: N/A

    ANGIOGENESIS IS A COMPLEX PROCESS INVOLVING THE PROLIFERATION, MIGRATION, AND PRECISE THREE DIMENSIONAL ALIGNMENT OF ENDOTHELIAL CELLS. A WIDE RANGE OF DISEASE PROCESSES INCLUDING SOLID TUMOR GROWTH, DIABETIC RETINOPATHY, INFLAMMATORY ARTHRITIS, AND PSORIASIS ARE ASSOCIATED WITH ABERRANT ANGIOGENESIS. IF RELATIVELY NON-TOXIC AGENTS WERE AVAILABLE TO INHIBIT ANGIOGENESIS SPECIFICALLY; MANAGEMENT OF ...

    SBIR Phase I 1991 Department of Health and Human Services
  5. ANTIBODY HETEROCONJUGATES FOR TREATMENT OF SIV INFECTION

    SBC: REPLIGEN CORPORATION            Topic: N/A

    THE GOAL OF THIS PROJECT IS TO GENERATE AND CHARACTERIZE A BISPECIFIC HETEROCONJUGATE ANTIBODY CAPABLE OF INDUCING THE CYTOLYSIS OF SIV-INFECTED CELLS. THE APPROACH IN PHASE I STUDY WILL ENTAIL CONJUGATING AN ANTI-CD3 MONOCLONAL ANTIBODY WITH AN ANTIBODY SPECIFIC FOR RECOMBINANT SIV ENVELOPE GLYCOPROTEIN GPL40. THE CYTOTOXIC ACTIVITY WILL BE TESTED IN AN IN VITRO SYSTEM USING CELLS INFECTED WITH R ...

    SBIR Phase I 1991 Department of Health and Human Services
  6. Development of Chemokines for Myeloprotection

    SBC: REPLIGEN CORPORATION            Topic: N/A

    We will develop a myelostatic agent to protect human hematopoietic precursor cells from the destrucchemotherapeutic agents currently used in the treatment of tumors. We propose that protection of preinhibition of growth during cancer treatment would reduce the toxicity associated with standard chemadministration of higher doses of chemotherapeutics without compromising the ability of the patientfu ...

    SBIR Phase I 1995 Department of Health and Human Services
  7. SUPPOSITORIES FOR RAPID ANTI-EPILEPTIC DIAZEPAM DELIVERY

    SBC: REPLIGEN CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 1991 Department of Health and Human Services
  8. Derivatives of uh 301 as Probes of the 5ht1a Receptor

    SBC: Research Biochemicals,            Topic: N/A

    Phase I describes a collaborative program that will synthesize a series of compounds related to(S)-5-F-8-hydroxy-2-(dipropylamino)tetralin [(S)-UH-301], an antagonist of the serotonin 5HT1A receptor.Recently RBI has developed a procedure for the efficient synthesis of (S)-UH-301 that makes it feasibleto envision the synthesis of analogs and derivatives described in this proposal. In particular, th ...

    SBIR Phase I 1994 Department of Health and Human Services
  9. Pd-128,907 Based Dopamine D3 Receptor Fluorescent Probes

    SBC: Research Biochemicals,            Topic: N/A

    Fluorescently amended analogs of the autoreceptor selective agonist PD- 128,907 will be synthesizedfunctionalization through suitable spacer units at ring amended nitrogen followed by coupling with fHigh enantiomeric excesses for all targets will be achieved either by classical resolution or througsynthesis of a late-stage intermediate common to both approaches. The affinity of each compound forth ...

    SBIR Phase I 1995 Department of Health and Human Services
  10. Synthesis of Cyclic ADP Ribose

    SBC: Research Biochemicals,            Topic: N/A

    We will develop the total synthesis of cyclic adenosine diphosphate ribose (cADPR). We envision a csynthesis in which the morpholine- activated phosphoroamidate N,N'-dicyclohexylcarboxamidine salt of'phosphate is coupled to 2,3,5-tri-O-benzoyl-D-ribose. The protecting groups will be removed and thecyclized to produce the desired final product, cADPR. The synthetic material will be fully charactert ...

    SBIR Phase I 1995 Department of Health and Human Services
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