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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. The Right Steps: A Virtual Reality Application/Intervention to Improve Wayfinding in Mild Cognitive Impairment (RightSteps)

    SBC: VIRTUALLY BETTER INC            Topic: NIA

    PROJECT SUMMARY ABSTRACTRightSteps This Phase I SBIR application responds to PAThe Right StepsA Virtual Reality ApplicationIntervention to Improve Wayfinding in Mild Cognitive ImpairmentRightStepswill create a virtual reality clinical training environment to deliver virtual wayfinding scenarios and a companion mobile phone application for real world rehearsal to assist in targeting wayfinding skil ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Production and commercialization of human glycosylation enzymes for chemistry and biology

    SBC: Glyco Expression Technologies (Corporation)            Topic: 300

    PROJECT SUMMARY Cell surface and secreted glycoproteins and glycolipids play critical roles in cellular physiology and pathologybut challenges remain in understanding how glycan based reagents can be leveraged for biochemical and therapeutic purposesA recent National Academies study concluded that there are numerous critical unmet needs for transformative methods and tools to fill technology gaps ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Noregen(TM), a regenerative medicine ocular therapeutic

    SBC: Retinal Solutions LLC            Topic: NEI

    Project Summary Diabetic retinopathy and Retinal Vein OcclusionRVOaccount for most new cases of blindness in the United StatesThese diseases are marked by retinal swellingedemaand new leaky vessel formationneovascularizationtriggered by pathologically high concentrations of Vascular Endothelial Growth FactorVEGFThe primary treatment is VEGF blocking drugs to control the neovascularization and edem ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Translational Development of a Targeted and Stroma-breaking Nanoparticle Drug for Pancreatic Cancer Therapy

    SBC: MIGRA-THERAPEUTICS LLC            Topic: 102

    Project Summary Resistance to therapy is the major clinical challenge in pancreatic cancer therapyLow efficiency in drug delivery and aggressive tumor biology are the major causes of a poor therapeutic responseIt is well known that the presence of a dense fibrous tumor stroma creates a drug delivery barrier and promotes aggressive biology and drug resistance in pancreatic cancer cellsThe objective ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Optimizing Usability of the Orally Rehydrate Children at Home Mobile Application- Optimize ORCAH

    SBC: Data2Care Technologies, LLC            Topic: NICHD

    Project Summary Abstract Acute gastroenteritisAGEinfectious diarrhea is a common condition that is costly in the US and highmortality in developing nationsThe cornerstone of AGE management is oral rehydration therapyORTan evidence based technique that has saved overmillion lives in theyears since its introductionThe problem we aim to address is ORT s underuse in developed countries specifically in ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Translating an In-Person Brief, Bystander Bullying Intervention (STAC) to a Technology-Based

    SBC: KLEIN BUENDEL, INC.            Topic: 102

    Project Summary While studies support the efficacy of comprehensiveschool wide interventions in reducing bullyingthese types of programs can require significant time and financial resources for implementationresulting in barriers to providing school based bullying preventionespecially in low income and rural communitiesAdditionallyalthough training bystanders to act asdefenderson behalf of targets ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Super-sensitive detection of BCR-ABL mutants driving CML recurrence

    SBC: GENETAG TECHNOLOGY, INC            Topic: 102

    Chronic myeloid leukemiaCMLis caused by a translocation between chromosomesandwhere the BCR gene promoter drives overexpression of ABL kinaseThis rearrangement causes transformation of bloodforming cells of the bone marrow and accounts forof all new leukemia cases in adultsThree generations of tyrosine kinase inhibitorsTKIshave been developed that are used clinically to inhibit the ABL kinase in C ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Developing an integrated virtual assistant (IVA): A tailored behavior tracking and reminder solution to assist persons with dementia and their caregivers

    SBC: Cloud Mustang Corporation            Topic: NIA

    Project Summary Abstract Recent attempts to estimate early stage prevalence of early stage dementia in the United States suggest that as much asof the population over the age ofmay be living with early stage diseaseIn early stagefunction lossparticularly in the memory domainsignificantly impacts instrumental activities of livingIADLsuch as responsibility for own medications and schedulingSolutions ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Cost effective nutritional therapy for managing sickle cell disease complications

    SBC: NutriGlobal, Inc            Topic: NHLBI

    Sickle cell diseaseSCDis a group of widespread single gene disorders and represents a significant public health burden worldwideIn the United Statesmost individuals with SCD are of African or Hispanic ancestrygroups often affected by healthcare disparitiesIncreased hemolysis of the fragilesickleshaped erythrocytesred blood cellsis characteristic of SCDThese red cells are destroyed and continuously ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Developing high-affinity nanobodies to tumor-associated glycan antigens

    SBC: VITAN-BIOTECH LLC            Topic: 300

    Project SummaryGlycans are known to be involved in including cell growth and differentiationcell cell communicationimmune responseand intracellular signaling eventsGlycans also feature prominently in human diseaseIn many different human disordersthe cellular glycome is alteredThe key unsolved problems in the glycosciences are the tools for study the temporal and spatial distribution of glycans on ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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