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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. IND-Enabling Development of a Small Molecule COVID Therapeutic

    SBC: OYAGEN, INC.            Topic: NIAID

    The proposed Phase I SBIR will conduct IND-enabling studies to establish the pharmacokinetics (PK) and SARS-CoV-2 (CoV-2) antiviral efficacy of sangivamycin (Sang) in Golden Syrian hamsters. Sang is an adenosine nucleoside analog that we discovered to be a potent, dose- dependent inhibitor of CoV-2 during in vitro viral infectivity studies conducted at the NIAID- Integrated Research Facility (IRF) ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Flu Vaccine Production Using a Novel Pandemic Response and Prevention Manufacturing Method

    SBC: SOLARIS VACCINES, INC.            Topic: NIAID

    PROJECT SUMMARY/ABSTRACT The current global pandemic has highlighted the need to develop new methods for creating vaccines. Many approaches today face limitations with breadth and duration of protection; flexibility and adaptability for emerging strains; manufacturing speed and safety; and storage and distribution. SolaVAX™ inactivation technology offers an elegant solution for quickly generatin ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Advanced Surgical Pathology Device

    SBC: SURGIVANCE INC.            Topic: 101

    Abstract Diagnosing diseases relies heavily on pathologically analyzing tissue samples from patients. For cancers alone, over 30 million people undergo tissue biopsies annually in the US. While surgery currently represents the best standard of care treatment to cure invasive cancers, its success depends on timely excision of the tumor before it can spread. This is especially true for the removal o ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Addressing Gaps in Language Access Services through a Patient-Centered Decision-Support Tool

    SBC: Transcendent International, LLC            Topic: NIMHD

    Project Summary Despite policies that mandate language access in healthcare settings, the growing population of individuals with limited English proficiency (LEP) in the United States encounters language barriers in the medical system that negatively impact patient outcomes and cause significant burdens on the health systems that struggle to deliver equitable care. This project will develop and pi ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Self-organizing synthetic human lungs on microchips to fight infection by RSV

    SBC: RUMI SCIENTIFIC, INC.            Topic: NIAID

    Project Summary RSV is a major global threat that accounts for a significant share of respiratory disease and mortality among patients at risk. Infection by highly pathogenic RSV results in acute lung injury, LRTI, and pneumonia-associated complications. As treatments for RSV are very limited in use and efficacy, the development of physiological models of this disease is key to develop therapeutic ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. IgE Suppressing Berberine Nanomedicine for Treatment of Food Allergies

    SBC: GENERAL NUTRACEUTICAL TECHNOLOGY LLC            Topic: NIAID

    ABSTRACTFood allergy (FA) has rapidly increased over 2 decades affecting 32 million Americans, with annual costs of $25 billion. FA anaphylaxis, a potentially life-threatening condition, increased 200-400% in children from toddlers to teens.10 Peanut/ tree nut and sesame allergy often co-exist, last a lifetime, cause severe reactions, and there is currently no cure. Common treatments, either proph ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Building a mathematical problem-solving environment to prepare K-5 students for success in STEM and health careers.

    SBC: TEACHLEY, LLC            Topic: 500

    Project Summary/AbstractThere is an enormous need for qualified people to pursue careers in STEM (Noonan, 2017). However, the lack of a strong foundation in mathematics means students are less likely to pursue STEM majors and careers (Chen, 2013; Griffith, 2010; Huang, Taddese, and Walter, E, 2000; Kokkelenberg and Sinha, 2010; Lowell et. al., 2009; Seo, Shen and Alfaro, 2019). Students from low-i ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Strep-CaDI: A fast, accurate, and sensitive point-of-care test for Group A Streptococcus

    SBC: BURST DIAGNOSTICS INC            Topic: NIAID

    SUMMARY The current rapid antigen detection tests for group A strep lack sensitivity and result in upwards of 10 million unnecessary antibiotic treatments provided to children each year. Current diagnostic methods utilized when a patient presents at a clinic with a sore throat include a throat swab and rapid strep test. A positive rapid test results in antibiotic prescription, but due to the low s ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. An innovative platform and smartphone app to deliver tailored interventions and facilitate completed referrals related to substance use.

    SBC: Chess Mobile Health, Inc.            Topic: NIDA

    Abstract The goal of this fast-track SBIR proposal is to increase patient adherence to SBIRT-related recommendations given to patients by a primary care provider (PCP). The success of SBIRT (Screening, Brief Intervention, and Referral to Treatment) in the primary care setting has been inconsistent in terms of patients following through on treatment referral recommendations, with averages as low as ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Development and clinical assessment of a robust, 3D printed titanium, myoelectric powered prosthetic digit system

    SBC: POINT DESIGNS, LLC            Topic: 106

    ABSTRACT Approximately 600,000 people live with partial hand amputations in the United States, with an estimated 14,500 new cases occurring each year. Despite the advances in miniaturized electronics and motors, there has been very little advancement in mechatronic prosthetic digits for this underserved patient population. In fact, to date, there is only one myoelectric prosthetic option for patie ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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