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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel Composite Dressing for Oxygen Transport in Exudating Wounds


    SUMMARY Chronic wounds are a significant health problemcases of which are increasing due to rising numbers of diabetic patientsan upsurge in obesityan increase in cardiovascular diseaseand an aging of the population in the USAEuropeJapanand ChinaClinical characteristics of chronic wounds are that they are hypoxichave low oxygen levelswhich hinders the healing processand are moderately to highly ex ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Construction and testing of a rabbit cornea-equivalent for evaluation of chemical injury in vitro


    ABSTRACTWe propose combination of the rabbit cornea endothelial and epithelial cells with bioengineered scaffolds in cell culture well insertsThis technology could significantly reduce the use of rabbits for the Draize rabbit eye irritation assayThe barrier to commercialization is the lack of an effective method for storingbankingof living bioengineered cornea equivalentsWe will combine cell expan ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Emodin as a complementary dietary therapy to reduce toxicity of 5 fluorouracil

    SBC: AcePre, LLC            Topic: R

    PROJECT SUMMARYfluorouracilFUhas been the first choice chemotherapy drug for colorectal cancerCRCfor many yearshoweverits clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non selectivitySide effects include fatigueloss of appetiteand diarrhea among othersall of which can lead to reduced quality of lifeThe economic burden associated with chemothe ...

    STTR Phase I 2018 Department of Health and Human Services
  4. Continuous removal/disposal system for the concurrent sorption and breakdown of contaminants into harmless precipitates

    SBC: Lynntech Inc.            Topic: NIEHS

    PROJECT SUMMARYThere is an ever growing need for useable uncontaminated water in the United States and across the globeThis increasing need includes many uses with the most significant being for potable waterHowevera significant problem is occurring at the confluence of industry and consumer that continues to put access to clean drinkable water at riskindustriesincluding oilmanufacturingagricultur ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Mitigating Injurious Falls in Older Adults Through Non-Injurious Fall and Gait Analysis From Floor Vibrations


    Project Summary and Abstract Falls are the leading cause of death due to injuryThis simple motion is so common thatof community dwelling older adultsandof long term care facilities will experience a fall in the coming yearThe risk of falling substantially increases for those having Alzheimer s disease and related dementiasand those with Parkinson s diseaseThe financial burden is significant with f ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Developing an automated yeast dissection system for aging research

    SBC: Innovative BioChips LLC            Topic: NIA

    PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...

    STTR Phase II 2018 Department of Health and Human Services

    SBC: INDUS INSTRUMENTS            Topic: NIA

    TITLEImplantable Wireless Telemetric Monitoring Device For Aging Studies In MiceABSTRACTThere has been a dramatic growth in aging research particularly using small animals such as mice to find translatable solutions to improve the health span as we ageWhile undisturbed and non tethered acquisition of physiologic data in awake mice using implantable wireless telemetry technologies reflects the most ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Development of Tetracycline Analogs for Alcohol Use Disorder Treatment

    SBC: South Plains Biotechnology, Inc            Topic: 350

    Project Summary Abstract Statement of the problemOnly three pharmacotherapeutic treatments for Alcohol Use DisorderAUDare FDA approved and none are widely usedandltof AUD patientsor show a strong effect to reduce riskyor dependence based drinking in the long termandltsee sustained decreased drinking outcomesUnfortunatelyapproximatelyof the population suffers from AUD and overof all medical morbidi ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Development and Production of Standardized Reference Diets for Zebrafish Research

    SBC: Meridian Biotech, LLC            Topic: 101

    The over arching goal of this Phase I SBIR proposal is to begin to optimize and implement standard reference diets for the ZebrafishDanio rerioan animal model of critical importance to the understanding of human health and development of vertebrate organismsA key problem in the industry is that standardized diets or feed management strategies have not been developed for Danio rerioThese diets are ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Dose-ranging safety and efficacy studies to advance novel mechanism-of-action drug candidates to reverse age-related muscle degeneration


    In the USthe number of individuals agedand older will increase byover the next decadeConcurrentlyMedicare costs are expected to double to treat chronic diseases that will plague this increasing number of older adultsOne of the most wide spread chronic diseases that affects older adults is sarcopeniawhich is observed inof adults overyears of age andof adults overyears of ageThis disease is characte ...

    STTR Phase I 2018 Department of Health and Human Services

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