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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Illuminating the "dark" kinases- effects on proteome translocation and chromatin binding

    SBC: TALUS BIOSCIENCE INC            Topic: 100

    Technologies for DNA sequencing and protein analysis have accelerated so rapidly that generation of infor- mation now outpaces our ability to completely understand it. As a result, many novel genes and proteins have been discovered, but their functions remain unknown. The intent of the current proposal is to illuminate the function of one group of these uncharacterized (“dark”) proteins, the k ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Promoting Healthcare Careers Through Interactive Digital Media STEM Exploration

    SBC: LIIINGO, INC            Topic: 500

    Project Summary The United States faces significant shortfalls recruiting and producing the healthcare professionals. In addition to staff shortages, the workforce is also burdened by a lack of racial and ethnic diversity. As a potential counter to these widening gaps, Liiingo’s healthcare career exploration game, Upward Knowbility, is a novel tool for secondary students to learn about career op ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Booth™ by Opio™: Developing technology to expand the reach of opioid treatment programs into rural and underserved areas.

    SBC: Opio Connect, Inc.            Topic: NIDA

    The goal of this project is to develop a treatment booth with technology that allows opioid treatment programs to remotely dispense, either methadone or buprenorphine, under medical observation through telemedicine to a patient in a treatment booth. We believe that robotic automation is the ideal application to perform the same mechanical functions of the nurse at the dosing window. Specifically, ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Bispecific Antibody for the Treatment of Idiopathic Pulmonary Fibrosis

    SBC: VIRTICI LLC            Topic: NHLBI

    Project Summary Our objective is to produce a bispecific antibody, VTC-890, capable of binding two proinflammatory cytokines, LIGHT (TNFSF14) and TL1A (TNFSF15), for the treatment of Idiopathic Pulmonary Fibrosis (IPF). IPF is a chronic fibrotic lung disease characterized by widespread progressive scarring of the lungs. Patients with IPF show declining lung function leading to early death 5, 47.We ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Expedited Expansion Cohort Clinical Trial for Relapsed/Refractory 'no-option' Non-Hodgkin's Lymphoma/Leukemia Patients

    SBC: AVM BIOTECHNOLOGY LLC            Topic: 102

    ABSTRACT Non-Hodgkin’s Lymphoma (NHL) is the 7th most common cancer in the U.S., with over half of the 77,240 people diagnosed annually over age 65. In about 50% of cases, disease recurs or relapses, typically within two years of initial treatment, and in some patients disease is refractory to additional treatment (Refractory/Relapsed, R/R). Salvage therapy in these patients consists of stronger ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Targeted Lymphoablation as an alternative to HSCT to cure T1D

    SBC: AVM BIOTECHNOLOGY LLC            Topic: 200

    PROJECT SUMMARY With insulin being the only approved treatment of Type 1 Diabetes (T1D), there is a very large unmet medical need for a definitive cure for pediatric and adult patients. In the U.S., diabetes currently affects 14% of the population of all ages, and it is the seventh leading cause of death, with an estimated cost of $237 billion every year to the healthcare system. The medical commu ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. 3D diagnosis of Hirschsprung disease using open-top light-sheet microscopy

    SBC: ALPENGLOW BIOSCIENCES, INC.            Topic: 300

    Abstract Hirschsprung disease is a congenital defect that affects an estimated 1:5000 liveborn infants. It is characterized by absent ganglion cells (neurons) in the distal rectum and a variable length of contiguous proximal bowel. The diagnosis of Hirschsprung disease relies upon subjective pathologist interpretation of up to 100 tissue sections from suction rectal biopsies to prove the absence o ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Small Molecule for the Prevention and Treatment of Diabetic Retinopathy

    SBC: EXCITANT THERAPEUTICS LLC            Topic: NEI

    SUMMARY Diabetic retinopathy (DR) is a leading cause of blindness in the United States. Currently, most treatments for DR are only applicable at the late stage and are invasive. Anti-VEGF (vascular endothelial growth factor) agents have achieved impressive therapeutic effects against DR and neovascularization (NV). However, 40% of patients with DR have inadequate responses to the treatment. Given ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  9. A Naloxone Parachute: Novel Wearable Dual-Sensor Regional Oximeter to Detect Opioid-Induced Hypoxia and Enable Emergent Naloxone Rescue

    SBC: AYUDA MEDICAL, LLC            Topic: NIDA

    SBIR PHASE II - ABSTRACTAyuda Medical has the vision that no-one should die from a treatable medical emergency. Opioid overdoses (OODs) are treatable with basic CardioPulmonary Resuscitation (CPR), but they claimed over 250 lives each day in the US in 2020. Patients most at risk for OOD are people in treatment for Opioid Use Disorder (OUD) or High Impact Chronic Pain (HICP). The current standard o ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a single-dose self-amplifying RNA vaccine for boosting pre-existing influenza virus immunity, driving B and T cell responses to conserved targets

    SBC: HDT BIO CORP            Topic: NIAID

    Project Summary While a universal influenza vaccine, providing life-long protective immunity against all current and future drifted and shifted subtypes of influenza virus after 2 or 3 doses, would be a game-changing solution to reducing the global burden of influenza and its associated morbidity and mortality, other approaches to solving this problem are urgently needed. There is still much to le ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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