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Project Summary AbstractThe objective of this proposal is to perform proof of concept experiments for a new thin walledsteerable sheath that can pass through a standard colonoscope port and dexterously maneuver surgical instruments at its tipClinical significance comes from the fact that overpatients per year in the USA have unnecessaryinvasive surgery to remove a section of their colonClinical li ...

Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

DESCRIPTION (provided by applicant): Attempts to develop drug treatments for acute stroke have not fulfilled expectations. Perhaps best illustrating this unsatisfactory situation is the hisory of therapeutic strategies directed at the inhibition of reactive oxygen species (ROS). While decades of laboratory and clinical studies make it clear that ROS are pathogenically important across the entire s ...

DESCRIPTION provided by applicant This Small Business Technology Transfer STTR Phase I project proposes to develop autonomously bioluminescent human stem cells for continuous reagent free and real time bioimaging to address the National Institutes of Healthandapos s request for new techniques for non invasive long term tracking of stem cell survivability engraftment and migration followi ...

Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...

The AEgis Technologies Group proposes to develop an innovative real-time thermal solver solution to model hardbody thermal histories. This thermal solver solution will consider the relevant phenomenology associated with MDA targets and other associated objects requiring thermal histories. Modeling of complex objects and advanced features such as model ablation and dynamic surface areas will be co ...

The results of the Phase I effort has identified the feasibility of real-time hardbody thermal solver algorithms on high performance hardware for use by MDA applications and real-time hardware-in-the-loop environments. Phase II development of the thermal solver will be expanded to include complex targets by expanding upon the techniques prototyped in Phase I. A new inline Parallel Euler Solver w ...

Fine powder thermal battery cathode materials can exhibit challenging flow properties which makes processing with automated presses difficult.Granulating these powders substantially improves flow properties and reduces the tendency for powder segregation during handling and pressing operations.The properties of Magnesium Oxide (MgO) that lead to good performance in thermal battery separators are n ...

Fine powder thermal battery cathode materials can exhibit challenging flow properties which makes processing with automated presses difficult.Granulating these powders can substantially improve flow properties and reduce the tendency for powder segregation during handling and pressing operations.Additionally, the properties of MgO that lead to good performance in thermal battery separators are not ...