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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Automated electrophysiological analysis of neural circuitry using a novel nano electrode array for intracellular recording of membrane potential

    SBC: CYION TECHNOLOGIES LLC            Topic: 101

    Summary Nervous systems process information by integrating the electrical activity of neurons in complex networks The alterations in the flow of electrical activity through neuronal networks of the brain play a causal role in the pathogenesis and or the appearance of symptoms of neurodegenerative and psychiatric diseases A fundamental goal of BRAIN Initiative is therefore to elucidate how the ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Gold nanoparticle laser warming of cryopreserved zebrafish embryos

    SBC: NANOCOMPOSIX, INC.            Topic: OD

    Project Summary Abstract In the past decade laboratories around the world have produced tens of thousands of mutant transgenic and wild type zebrafish lines for a wide range of genetic and biomedical research Maintaining all of these valuable genotypes is expensive risky and beyond the capacity of even the largest stock centers Cryopreservation of zebrafish sperm eggs and embryos is vital ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Next Generation Regenerative Therapy with Pim Enhanced Cardiac Progenitor Cells

    SBC: CardioCreate, Inc.            Topic: NHLBI

    PROJECT SUMMARY Myocardial regenerative therapy is poised to revolutionize the way heart failure is treated but further improvements and enhanced products are needed to make this therapy truly safe and efficacious Our company CardioCreate Inc has pioneered the use of genetic engineering to enhance the regenerative potential of human Cardiac Progenitor Cells CPCs intended for autologous the ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Assessment of the glucagon receptor blocker REMD-477 on insulin requirements in type 1 diabetes

    SBC: REMD BIOTHERAPEUTICS INC.            Topic: NIDDK

    DESCRIPTIONprovided by applicantFast TrackInsulin remains the primaryand often the onlytreatment for typediabetes mellitusT DHowever it is associated with chronic iatrogenic hyperinsulinemiasecondary hyperlipidemiahigher incidence and severity of cardiovascular complicationsand life threatening hypoglycemia eventsA higher mortalityvsdue to cardiovascular complications were reported in insulin trea ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. I- Corps Administrative Supplement to Novel Reagents for Breast Tumor SPECT Imaging R41CA217546

    SBC: Cavatar LLC            Topic: NCI

    PROJECT SUMMARY Early cancer detection and diagnosis are critical for patient survival and treatment successFor the imaging of breast and other solid tumorsthe diagnostic power of advanced imaging techniques such as SPECT could benefit tremendously from improved contrast agents that rapidly and selectively accumulate in tumor lesions and produce high tumor to background signal ratiosWe are develop ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Trans‐nasal delivery of chemotherapy to glioblastoma using magnetic nanoparticles and magnetic focusing

    SBC: WEINBERG MEDICAL PHYSICS, INC.            Topic: 102

    Abstract Glioblastoma multiforme GBM is the deadliest form of brain tumor The current treatment includes a combination of surgical resection chemotherapy radiation and electrical disruption of mitosis has only extended survival to approximately to years Preliminary pre clinical findings suggest the potential effectiveness of the candidate drug cyclopamine However the drug is toxic to ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of Pirenzepine for CIPN

    SBC: WinSanTor, Inc.            Topic: O

    PROJECT SUMMARY Chemotherapy induced peripheral neuropathy CIPN is a debilitating complication that can arise from use of a number of chemotherapeutics and which limits both the dose and duration of cancer treatments with these agents Up to of cancer patients treated with chemotherapy describe some form of CIPN with sensory neuropathy being dominant Symptoms vary from tingling and numbne ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. SA FasL engineered human islets as a novel product for the treatment of type diabetes

    SBC: FasCure Therapeutics LLC            Topic: NIDDK

    PROJECT SUMMARY Type diabetes T D is a chronic autoimmune disorder that affects of population worldwide Exogenous insulin treatment is the standard of care for T D but often negatively affects the quality of life and is ineffective in preventing recurrent hyperglycemia episodes and chronic complications Recent studies show that human islet allografts can restore long term normoglycemia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Enabling point of care molecular diagnostics by developing an adaptive PCR instrument and on demand kit reagents

    SBC: BIOVENTURES, INC            Topic: 172

    Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a new small molecule therapeutic for the treatment of resistant breast cancer

    SBC: VioMedix, LLC            Topic: 102

    PROJECT SUMMARYABSTRACTBreast cancer is the second leading cause of death in females with cancerInapproximatelynew cases of invasive breast cancer were diagnosedwhere an estimate ofwas expected to succumb to their diseaseIt is estimated that one in eight women will develop breast cancer in their lifetimeBreast cancer is classified into subtypes based on the expression of estrogen receptorERprogest ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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