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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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SBC: Integrated Biotherapeutics, Inc. Topic: r
Project Summary The Gram positive bacterium Bacillus anthracis is a very strong candidate for potential bioweaponizationand believed to have actually been weaponized by the former Soviet UnionAnthrax spores are readily found in nature or produced in the laboratoryare resistant to harsh conditionsand can survive for a long time in the environmentThe microscopic spores could be formulated in powder ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: GENVEC, INC. Topic: 100
Project Summary The exceptional promise of gene therapy for hemophilia has been shown in recent studies that result in long term correction of factor IX deficiency via hepatic transduction with an adeno associated vector AAV In spite of this watershed event in the history of the gene therapy field there presently exist barriers to the fullest implementation of hemophilia gene therapy The li ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: ZYMO RESEARCH CORP. Topic: 101
PROJECT SUMMARY ABSTRACT Stroke injury is a process that occurs over a long duration with pathologic changes that result in long term neurologic dysfunction For stroke there exists an important need for a strategy that can provide safe and efficacious stabilization to the hypoperfused brain and initialize long lasting endogenous neuroprotection for prevention of long term neurologic dysfunction ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Automated electrophysiological analysis of neural circuitry using a novel nano electrode array for intracellular recording of membrane potentialSBC: CYION TECHNOLOGIES LLC Topic: 101
Summary Nervous systems process information by integrating the electrical activity of neurons in complex networks The alterations in the flow of electrical activity through neuronal networks of the brain play a causal role in the pathogenesis and or the appearance of symptoms of neurodegenerative and psychiatric diseases A fundamental goal of BRAIN Initiative is therefore to elucidate how the ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: NANOCOMPOSIX, INC. Topic: OD
Project Summary Abstract In the past decade laboratories around the world have produced tens of thousands of mutant transgenic and wild type zebrafish lines for a wide range of genetic and biomedical research Maintaining all of these valuable genotypes is expensive risky and beyond the capacity of even the largest stock centers Cryopreservation of zebrafish sperm eggs and embryos is vital ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: CardioCreate, Inc. Topic: NHLBI
PROJECT SUMMARY Myocardial regenerative therapy is poised to revolutionize the way heart failure is treated but further improvements and enhanced products are needed to make this therapy truly safe and efficacious Our company CardioCreate Inc has pioneered the use of genetic engineering to enhance the regenerative potential of human Cardiac Progenitor Cells CPCs intended for autologous the ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: WinSanTor, Inc. Topic: O
PROJECT SUMMARY Chemotherapy induced peripheral neuropathy CIPN is a debilitating complication that can arise from use of a number of chemotherapeutics and which limits both the dose and duration of cancer treatments with these agents Up to of cancer patients treated with chemotherapy describe some form of CIPN with sensory neuropathy being dominant Symptoms vary from tingling and numbne ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: FasCure Therapeutics LLC Topic: NIDDK
PROJECT SUMMARY Type diabetes T D is a chronic autoimmune disorder that affects of population worldwide Exogenous insulin treatment is the standard of care for T D but often negatively affects the quality of life and is ineffective in preventing recurrent hyperglycemia episodes and chronic complications Recent studies show that human islet allografts can restore long term normoglycemia ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Enabling point of care molecular diagnostics by developing an adaptive PCR instrument and on demand kit reagentsSBC: BIOVENTURES, INC Topic: 172
Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: VioMedix, LLC Topic: 102
PROJECT SUMMARYABSTRACTBreast cancer is the second leading cause of death in females with cancerInapproximatelynew cases of invasive breast cancer were diagnosedwhere an estimate ofwas expected to succumb to their diseaseIt is estimated that one in eight women will develop breast cancer in their lifetimeBreast cancer is classified into subtypes based on the expression of estrogen receptorERprogest ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health