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SBC: SIGNAL SOLUTIONS, LLC Topic: 100
Noninvasive Seizure Screening in Preclinical Models of Epilepsy There is an urgent need for research into treatment options for epilepsy and other seizure disordersAnimal models are increasingly used to understand disease mechanisms and to screen promising therapeutic approachesAnimal epilepsy model use typically requires expensive and labor intensive experimentationwith invasive EEG measurements ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: NEONC TECHNOLOGIES INC Topic: 102
Project Summary Abstract Many pharmaceutical agents are highly potentbut are unable to exert substantial therapeutic activity against disorders of the brainbecause the blood brain barrierBBBeffectively prevents their access to the site of intracerebral diseaseFor examplethe majority of glioblastoma patientsdespite the best efforts of current medical caredie within two years after diagnosisHencethe ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: MR-LINK LLC Topic: 101
Project Summary The use of technologies for imagingrecording and modulating brain activity is rapidly advancing neuroscienceNotablymicroelectrodes are used to locally record neural activity or to perturb circuit functionFunctional magnetic resonance imagingfMRIis widely used to image large scale patterns of hemodynamic fluctuations accompanying neural activityAlthough these techniques have become ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Formation and Structural Property Relationships of a Tetracalcium Phosphate Bone Adhesive BiomaterialSBC: RevBio, Inc Topic: NIA
Project Abstract Approximatelyof all fractures occur in the small bones of the wristshands and feetamounting to more thanmillion annuallyConsidering functional losses associated with the locations of these injuriesproper reduction and fixation is critical to ensure optimal rehabilitation and recoveryComplex injuries that include irreducible fractures or segmental bone loss require operative fixati ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Leaflabs, LLC Topic: 101
PROJECTSUMMARY Scaling extracellular electrophysiology to higher channel counts is hindered by the burden of data handling storageand especially preprocessinge gspike sortingThe burden of spike sorting can in principle be reduced through a combination of high density multielectrode arrayprobetechnology and algorithm optimization to yield a spike sorting method that is both highly accurate and full ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: BIOSENSICS LLC Topic: NIA
Project Summary The overall goal of the proposed work is to develop a platform capable of delivering and monitoring adherenceproficiencyand safety of a home based simplified Tai Chi intervention for older adultsDuring Phase I of this Fast Track STTR project we will further develop a novel approach to assessing Tai Chi performance adherenceproficiencyand safety based on wearable sensor dataMetrics ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: BIOSENSICS LLC Topic: NIA
ABSTRACT The recent shift in Alzheimer s diseaseADclinical research from clinical diagnosis toward the goal of developing neuroprotective therapies has highlighted the need for a robust and rapidly administered cognitive assessment tool capable of identifying individuals in the earliest stages of cognitive decline and measuring subtle changes in cognitive motor performance over timeIn this context ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: DFUSION INC. Topic: NICHD
Althoughyear olds are onlyof the U Ssexually active populationthey account for nearlyof themillion new cases of sexually transmitted infectionsSTIeach yearAlthough historically lowthe U Steen pregnancy rate continues to be one of the highest in the developed worldEvidence based prevention efforts can help avoid the costs and health consequences associated with STIs and unwanted teen pregnancy amon ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: NGOGGLE INC Topic: N
PROJECT SUMMARY Assessment of loss of visual function outside the foveal area is an essential component of the management of numerous conditionsincluding glaucomaretinal and neurological disordersDespite the significant progress achieved with the development of standard automated perimetrySAPmany decades agoassessment of visual field loss with SAP still has significant drawbacksSAP testing is limi ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: INTELON OPTICS, INC. Topic: N
ABSTRACT The overall goal of this STTR project is to commercialize a novel optical eye scanner device capable of measuring the biomechanical properties of tissues via Brillouin light scatteringThe Brillouin technology invented in the co PI s lab has shown broad potential for improving the diagnosis and treatment of vision disordersClinical data obtained with current laboratory systems revealed cor ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health