Award Data

DESCRIPTION (provided by applicant): The objective of this proposal is to complete development of a long-term, universal Apical Access System (AAS) to improve clinical outcomes and expand the role of left ventricular assist device (LVAD) therapy. The treatment of end stage heart failure (HF) is the greatest challenge, both clinically and economically to the U.S. health care system today. With gt80 ...

DESCRIPTION (provided by applicant): Adolescents in mental health treatment are at greater risk for HIV and other STIs than their peers due to an earlier age of onset of sex, less protected sex, more sexual partners, and more frequent substance use. This greater risk is due to multiple factors including cognitive misperceptions, affect dysregulation, and less self efficacy. The numerous adolescent ...

ABSTRACT Tobacco-related deaths cost the United States approximately 200 billion each year. Nicotine is singularly responsible for the dependence-forming properties of tobacco smoking and, once introduced to the body, affects the brain within 15 seconds.Breaking nicotine addiction is challenging and relapse rates remain high. The extremely rapid timescale of nicotine action renders existing techn ...

DESCRIPTION (provided by applicant): This Phase II SBIR proposal aims at the continued development and commercialization of a new class of high-performance X-ray imaging screens based on the recently developed core/shell nanorod (NR) and nano-tetrapods (NTs) structures. These multi-dimensional nanocrystalline (NC) structures can be easily embedded with high densities in transparent polymer matrice ...

DESCRIPTION (provided by applicant): The objective of this Fast Track Small Business Innovation Research (SBIR) application, submitted by KDH Research and Communication (KDHRC), is to develop and evaluate the School TIME Toolkit (Toolkit) to support parents and teachers of elementary school-aged children who have a chronic illness and intermittent school attendance (CICISA). Children with chronic ...

DESCRIPTION (provided by applicant): In response to the program announcement for Phase IIb proposals for complex, in-vitro brain and behavior tools (PA-11-135), this proposed study automates all aspects of in-vitro Microelectrode Array (MEA) technology todeliver the first ever high throughput MEA-based screening system. This development will not only enable rapid advancements in the study of basic ...

Access to a library of structurally defined N-glycans is an urgent scientific need for glyco-arrays for rapid analysis of carbohydrate binding proteins (CBPs), development of diagnostics and therapeutics for many diseases. However, only a small number ofN-glycans are currently commercially available, which hampered researches in Glycobiology. This application will chemo-enzymatically prepare a ...

Not Available

A mobile computing application will be developed for Apple iOS and Google Android based mobile devices. This application will be targeted towards healthcare providers who make routine use of mobile devices in their daily work. The application will be capable of capturing all information required for submission to the Vaccine Adverse Event Reporting System (VAERS) and securely transmitting the info ...

DESCRIPTION Glycans have several distinct properties that make them excellent targets for disease biomarkers Firstly the location of the glycans on the cell surface makes them the first point of contact of cellular interactions and thus crucial in the control of normal metabolic processes Cell surface molecules are also strategically exposed for surveillance by the immune system allowing for ...