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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Phase a clinical trial of ALK in geographic atrophy

    SBC: ALKEUS PHARMACEUTICALS, INC.            Topic: NEI

    DESCRIPTION provided by applicant The long term goal of this work is to develop an oral drug for the prevention of age related macular degeneration AMD AMD is the leading cause of blindness in the United States with million Americans diagnosed or at risk of irreversibly losing vision and over million people who already have debilitating vision loss Currently there is no FDA approved ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Kinome wide Cell Based Assays

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: 300

    DESCRIPTION provided by applicant The human genome encodes protein kinases that catalyze the phosphorylation of client proteins Signal transduction mediated by protein impacts virtually all aspects of cellular physiology from the coordination of the cell cycle and cll division to apoptosis Not surprisingly the deregulation of kinases is implicated in many diseases including diabetes in ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Automated Problem and Allergy Lists Enrichment Based on High Accuracy Information Extraction from the Electronic Health Record

    SBC: Clinacuity, Inc            Topic: NCI

    DESCRIPTION provided by applicant Medical errors are recognized as the cause of numerous deaths and even if some are difficult to avoid many are preventable Computerized physician order entry systems with decision support have been proposed to reduce this risk of medication errors but these systems rely on structured and coded information in the electronic health record EHR Unfortunately ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Empowering real time web based genomic big data analysis at commercial scale

    SBC: Frameshift Labs, Inc.            Topic: 172

    DESCRIPTION provided by applicant The academic iobio project delivers web based applications that visualize and provide real time interactive analysis with multiple different data types generated as part of next generation sequencing projects These applications are open source and provided for free This proposal aims to develop critical computational infrastructure to enable the iobio project ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. C i Supplement Development of an Active Spinal Orthosis for the Treatment of Vertebral Compression and Burst Fractures

    SBC: EXO DYNAMICS LLC            Topic: NIBIB

    Significance of Research Exo Dynamics seeks to develop a novel active spinal orthosis that will enhance the outcomes of bracing treatment for the most common osteoporotic spinal fractures The goal is to create a device that will enhance outcomes through monitored use and provide consistent continuous support through a complete range of motion ROM This device may reduce pain enhance mobilit ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. BPN Safety and Cognitive Effect in Young and Elderly Subjects

    SBC: TETRA DISCOVERY PARTNERS, INC.            Topic: NIA

    Project Abstract Tetra Discovery Partners is seeking Phase II SBIR funding for a multiple ascending dose human Phase clinical trial of BPN to evaluate safety tolerability pharmacokinetic and cognitive profile in healthy young and elderly male and female subjects BPN is a first in class phosphodiesterase D negative allosteric modulator PDE D NAM that targets the protein kinase A ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Sustained release gel enabling one stage treatment of prosthetic joint infection

    SBC: SONORAN BIOSCIENCES, INC.            Topic: NIAMS

    Principal Investigator Overstreet Derek J Abstract Sonoran Biosciences Inc SBIR PAR Direct Phase II Prosthetic joint infections PJIs are especially costly requiring two surgeries at a cost of approximately $ per case to treat more than hip and knee replacement infections each year The near term outlook in this area is bleak with the number of infections growing ov ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Glycosaminoglycans to Treat and Prevent Radiation Induced Oral Mucositis

    SBC: GLYCOMIRA, LLC            Topic: NIDCR

    ABSTRACT Oral mucositis is a devastatingly painful inflammatory disease that frequently develops during cancer therapy and affects half a million people in the US The accompanying pain is so severe that patients often require narcotic pain medicines The clinical manifestations are ulcers in the mouth and gastrointestinal tract which are exacerbated by opportunistic infections Many patients al ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Microfabricated Cochlear Electrode Array

    SBC: MEMStim LLC            Topic: NIDCD

    Project Summary Abstract Current cochlear implants while beneficial in their use are limited in their capabilities by hand assembly of the electrode arrays This tedious manufacturing method is very costly extremely labor intensive and inadequate in implementing new technologies for improving speech recognition and music appreciation A superior alternative to hand assembly is microfabricati ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds II

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: 300

    DESCRIPTION provided by applicant In the manufacture of pharmaceutical compounds organic syntheses are often carried out in organic solvents These solvents must then be separated from high value intermediates and active pharmaceutical ingredients APIs in order to produce the final product medications Many intermediate compounds and APIs are thermally labile and thermal separation processes ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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