Award Data

DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is the second leading cause of cancer deaths in the U.S and Western world. Despite increased screening and advances in treatment, the mortality rate (~50,000/year) and high national health-care burden for CRC is likely to remain high unless more effective methods are developed to predict recurrence and response to chemo-radiation ther ...

DESCRIPTION provided by applicant The declining cost of whole exome sequencing WES is nearing the point at which the spread of WES into clinical practice will be limited largely by the cost of interpreting the results and comparing them to the patientandapos s clinical findings This project builds on our demonstrated capability to reduce this interpretation cost by pairing our diagnostic sof ...

DESCRIPTION (provided by applicant): This research project, presented as a fast-track SBIR proposal, deals with a new gene expression-based approach to the diagnosis and biological characterization of lung cancer in current and former smokers being evaluated for the possible diagnosis of lung cancer. Allegro Diagnostics is developing a portfolio of lung cancer biomarker products that are based o ...

DESCRIPTION (provided by applicant): This Fast-track application addresses the problem of teaching children with autism and related intellectual disabilities to discriminate among items of relatively greater or lesser symbolic value. The context for instruction is an evolving suite of computer-based and computer-managed matching-to-sample programs for teaching functional money skills. Foundational ...

DESCRIPTION provided by applicant The advent of high density DNA microarrays almost years ago has been an essential step in the genomics revolution Major successes include genome wide gene expression profiling GEP which has led to a new understanding of cellular control pathways and powerful diagnostic prognostic tests such as for predicting breast cancer recurrence In principle a simi ...

DESCRIPTION (provided by applicant): Kidney disease in the United States has been described as an epidemic. More than 20 million patients have chronic kidney disease (CKD) and these numbers are increasing annually. As a result, the number of patients with end-stage renal disease (ESRD) is expected to double between 1999 and 2010. These increases in CKD and ESRD are associated with significant morb ...

DESCRIPTION provided by applicant Physical Sciences Inc PSI in collaboration with Memorial Sloan Kettering Cancer Center MSKCC and Caliber Imaging andamp Diagnostics Inc Caliber ID proposes to develop a hand held reflectance confocal microscopy optical coherence tomography RCM OCT imaging probe and clinically evaluate its potential use for guiding laser ablation therapy of BCC b ...

DESCRIPTION (provided by applicant): Hands-on training is a widely accepted methodology, especially for learning clinical procedures as they can be complicated and difficult to master. Virtual Reality (VR) based training systems can be highly successful in training operators because they can be accessed anytime anywhere as a refresher without the need for a human expert, can simulate various scena ...

DESCRIPTION provided by applicant High Cell Density Bioartificial Pancreas Enabled by Implantable Oxygen Generator The overall goal of the SBIR project is to develop and test a human scale BioArtificial Pancreas with Implantable Oxygen Supply BAPIOS tm This consists of a miniaturized implantable electrochemical oxygen generator EOG that will continuously supply oxygen to islets or cells ...

DESCRIPTION (provided by applicant): High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Abstract Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a radionuclide throughout the body of a human patient or a research animal. Typically, the collected data are d ...