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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. AlgenML: Drug target discovery platform for transcriptional reprogramming of MYCN-driven neuroblastoma

    SBC: Algen Biotechnologies Inc            Topic: 400

    AlgenML: Drug target discovery platform for transcriptional reprogramming of MYCN-driven neuroblastoma PROJECT SUMMARY Drug discovery is a laborious, time-consuming, and expensive undertaking for biopharma. Oncology is especially difficult with new drugs in clinical trials having just 3.4% probability of success. This application addresses significant challenges of traditional drug target discover ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Alkoxylamine nucleosides for sequencing by synthesis

    SBC: INTELLIGENT BIO-SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Sequencing during synthesis (SdS) is an architecture for massively parallel DNA sequencing that has the strong potential of lowering the cost of sequencing enough to allow individuals access to their own genetic heritag e as a way of personalizing their medical care. Thus far, however, higher-throughput next-generation sequencing systems are relatively expensiv ...

    STTR Phase II 2008 Department of Health and Human ServicesNational Institutes of Health
  3. Alkylating Vitamin D Derivative

    SBC: APHIOS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Prostate cancer is the most prevalent cancer among men; and the second leading cause of cancer death among men in the US. There are currently no approved therapies for hormone-refractory prostate cancer. Epidemiological studies have demonstrated a strong relationship between incidence of and mortality from various cancers including prostate cancer, exposure to ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  4. Allergen???Fc-gamma1 proteins to treat food allergy

    SBC: TUNITAS THERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The goal of this proposal is to develop and commercialize a novel approach for allergen specific immunotherapy as treatment for severe food allergy. Food allergy affects about 3.5% of the US population and 6% to 8% of young children. It is clearly on the rise. Peanut allergy, which affects around 1% of the population, is among the most severe food allergies, r ...

    STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  5. Allosteric Drug Discovery using Quantum Cascade Laser based Anisotropic THz Microscope (QCL-ATM)

    SBC: LONGWAVE PHOTONICS LLC            Topic: 400

    Allosteric Drug Discovery using Quantum Cascade Laserbased Anisotropic THz Microscope (QCL-ATM) Proposal in Response to NIH/NIGMS STTR PA-20-265 This STTR will result in a commercially viable instrument that will enable critical research in allosteric drugs and protein dynamics. To date allosteric inhibitors are largely found serendipitously. Anisotropic THz microspectroscopy (ATM) uniquely measur ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. A low-cost point-of-care diagnostic test for simultaneous HIV-1 and STI

    SBC: Infoscitex Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): An important approach for HIV/AIDS prevention is to diagnose co-infections that significantly increase the transmission of HIV. In this proposal, we propose to develop a rapid point-of-care (POC) test that simultaneous ly diagnoses HIV-1 and two sexually transmitted infections (STI's). Syphilis and genital herpes are STI's that enhance HIV transmission; if dia ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  7. A Luminal Vascular Coating to Prevent Intimal Hyperplasia Following Creation of a

    SBC: Symic Bio, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): This proposal addresses PHS 2012-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]). More than 20 million American adults (1 in 10) have some level of chronic kidney disease (CDC), with a growing incidence in the aging population. Nearly 400,000 ESRD patients receive some form of dialysis, with t ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  8. AMBULATORY SYSTEMS FOR THE MEASUREMENT OF HUMAN MOTION

    SBC: Graves Electronics            Topic: N/A

    N/A

    STTR Phase I 1998 Department of Health and Human Services
  9. Amelioration of opioid withdrawal-induced anxiety and craving with heterodyned whole body vibration

    SBC: PHOTOPHARMICS, INC.            Topic: NIDA

    PROJECT SUMMARY Opioid use disorder (OUD) is a rising problem in the United States and around the world, with pain and stress being major factors for initial drug seeking and relapse. The mesolimbic dopamine (DA) system originating in the midbrain ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAc) in the striatum is an important nexus for the rewarding properties of opioids ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Amelioration of rhinovirus induced asthma exacerbations by serpin B1

    SBC: SERPLUS TECHNOLOGY LLC            Topic: NIAID

    PROJECT SUMMARY Asthma exacerbations are a major cause of ER visits and hospitalizations with annual direct costs of approximately $billionyear in the USAViral infectionsin particular rhinoviralRVinfectionsare a major precipitant of asthma exacerbations in allergic asthmaticsAs there are overRV serotypes andfor nowno RV vaccinenovel strategies to inhibit RV induced airway inflammation are needed t ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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