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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Therapeutic targeting of FKBP51 for the prevention of stress-induced preterm birth
SBC: DARE BIOSCIENCE, INC. Topic: NICHDIn the United States, one in ten babies is born prematurely. The earlier in pregnancy a baby is born, the more likely they will have an extended hospital stay, as well as serious health complications such as respiratory distress syndrome, necrotizing enterocolitis, deafness, vision problems and cerebral palsy. Maternal stress is a well-established risk factor for preterm birth, and recent studies ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
A Novel Therapeutic to Promote Corneal Repair
SBC: MICROCURES INC Topic: NEIThe cornea is one of the most important tissues in the eye and its transparency is critical for good visual function in humans. Corneal tissue injuries are the most common, everyday issue for practicing ophthalmologists and can run the gamut in severity. Healing of large corneal wounds, such as alkali burns, involves extended migration of epithelial cells as well as reinnervation of the cornea. Ho ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Substance Use Disorder Artificially Intelligent chatbot for screening, assessment and referral: SUD Bot
SBC: Clinic Chat LLC Topic: NIDAABSTRACT The opioid epidemic is considered one of the most severe public health crises we are facing in the U.S. and is worsened by use of stimulants such as methamphetamine. The US Preventive Services Task Force (USPSTF) recommends screening for unhealthy drug use accompanied by offers of and referrals to services that include accurate diagnosis, effective treatment and appropriate care of a subs ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Image-based risk assessment to identify women at high-risk for breast cancer
SBC: WAVED MEDICAL LLC Topic: NCI7. PROJECT SUMMARY Breast cancer is the most common cancer worldwide and the most common cancer diagnosed in American women. While there has been good progress regarding detection and treatment methods, breast cancer remains the primary cause of death from malignant tumors. Hence, there is a critical need for the development of novel predictive and prognostic factors. Risk assessments are currentl ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Phase 1 Trial to Assess Safety and Immune Effects of Xenon Gas in Healthy Human Subjects
SBC: General Biophysics LLC Topic: NIAPHASE II APPLICATION(STTR Program PAS-22-197) “Phase 1 Trial to Assess Safety and Immune Effects of Xenon Gas in Healthy Human Subjects” ABSTRACTAlzheimer’s disease (AD) is one of the most prevalent neurodegenerative disorders. Emerging evidence shows that homeostatic dysregulation of the brain immune system, especially that orchestrated by microglia, plays a significant role in the onset an ...
STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Acute Disseminated Encephalomyelitis (ADEM)
SBC: TRIANGLE THERAPEUTICS INC. Topic: NIAIDPROJECT SUMMARY Acute disseminated encephalomyelitis (ADEM) is an acute autoimmune disease that can present with fever and ataxia as well as loss of consciousness and coma. ADEM largely affects children, is driven by T and B lymphocytes aberrantly activated against a myelin antigen, and is strongly associated with a prior infection or immunization. There is no FDA-approved therapy for the treatmen ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Systemic Lupus Erythematosus
SBC: TRIANGLE THERAPEUTICS INC. Topic: NIAIDPROJECT SUMMARY Lupus is a chronic, systemic autoimmune disease in which cells of the immune system attack organ systems throughout the body including the kidneys, brain, and lungs and that presents heterogeneously with symptoms that can include fever, arthritis, alopecia, stroke, and heart attack. Lupus is driven by autoreactive B and CD4 T cells with a particular role for TfH and TH17 CD4 T cell ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
A Precision Medicine for Alcohol-Associated Liver Disease
SBC: GENETOBE INC Topic: 150ABSTRACT The goal of this study is to develop an RNAi-based genetic precision medicine to treat alcohol associated liver disease (AALD). AALD is a devastating health problem worldwide, accounts for the majority of alcohol-related mortality globally and is the second most indication for liver transplantation in the US. The current medical management for AALD remains limited, and no proven pathobiol ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Advanced optics to unlock large field-of-view multiphoton imaging for neuroscience and beyond
SBC: PACIFICOPTICA LLC Topic: 101Project summary Currently available optical components limit biomedical imaging. In particular, in neurobiology, standard microscope components limit the field-of-view and speed of imaging of neuronal activity. Through prior work on BRAIN Initiative project, we have developed approaches for new optical components that expand the field-of-view 5 to 50 times over standard microscopes, with no loss i ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Feasibility of app-delivered circadian synchronization therapy with light in a cohort of pregnant women
SBC: ARCASCOPE INC. Topic: NICHDPROJECT SUMMARY Circadian rhythms play a vital role in promoting maternal health and managing pregnancy outcomes, including gestational diabetes, preterm birth, and postpartum depression. However, interventions to mitigate circadian rhythms disruption during pregnancy are lacking, despite readily available non-pharmacological circadian interventions. The circadian timekeeping system is strengthene ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health