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SBC: MAPP BIOPHARMACEUTICAL, INC. Topic: CBD18A002
There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
SBC: Flow Pharma, Inc. Topic: CBD18A002
Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
SBC: IREPROGRAM, LLC Topic: ST17C001
Methods for interconversion between cell types (cellular reprogramming) are currently discovered through resource intensive trial and error. Experiments may test a multitude of transcription factors to identify correct combinations that influence cell fate. In addition, reprogramming approaches commonly use stem cell intermediates such as induced pluripotent stem cells (iPSCs), which are generated ...STTR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
SBC: Systems & Technology Research LLC Topic: ST17C003
The unique scale, population density, complexity, and connectedness of megacities requires new tools for detecting and assessing risks related to civil unrest, rule of law, terrorism, and other sources of instability, and for understanding the underlying dynamics. In addition, gray zone operations pose a new and strategically important class of threats to the stability of nation states and cities ...STTR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
SBC: BOSTON FUSION CORP Topic: ST17C003
Boston Fusion Corp. and Arizona State University will research and develop REsilience & Stability in DENse Terrains (RESIDENT), a multi-model, multi-scale framework for assessing indicators of stability and resilience in dense urban environments. Our team consists of subject matter experts in the Social and Computer Sciences providing the bedrock on which to build accurate mathematical models of u ...STTR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
SBC: TRITON SYSTEMS, INC. Topic: DHA17C002
Triton Systems, Inc. proposes to develop a piezo-textile that can capture underwater explosion pressure wave patterns to ultimately establish and monitor for injury risk severity. We propose to use a state-of-the-art piezo-textile to which we will apply our own proprietary treatments.We will assess our textiles pressure detection performance and durability against a non-textile piezoelectric array ...STTR Phase I 2018 Department of DefenseDefense Health Agency
SBC: WEINBERG MEDICAL PHYSICS, INC. Topic: DHA18A001
There is an urgent need to bypass or cross the blood brain barrier (BBB) to deliver drugs for TBI treatment. This project aims to develop targted intranasally delivered, magnetically propulsed, and targted nanoparticles for traumatic brain injury (TBI). In Phase I, we will demonstrate the design, fabrication, and in vitro characterization of proposed drug laden magnetic nanoparticles as well as co ...STTR Phase I 2018 Department of DefenseDefense Health Agency
SBC: X-Wave Innovations, Inc. Topic: DLA18A001
Additive Manufacturing (AM) is a modern and increasingly popular manufacturing process for metallic components, but suffers from well known problems of inconsistent quality of the finished product. Process monitoring and feedback control are therefore crucial research areas with a goal of solving this problem. To address this concern, X-wave Innovations, Inc. (XII) and the University of Dayton Res ...STTR Phase I 2018 Department of DefenseDefense Logistics Agency
Hybrid DNN-based Transfer Learning and CNN-based Supervised Learning for Object Recognition in Multi-modal Infrared ImagerySBC: TOYON RESEARCH CORPORATION Topic: 1
On this effort Toyon Research Corp. and The Pennsylvania State University are developing deep learning-based algorithms for object recognition and new class discovery in look-down infrared (IR) imagery. Our approach involves the development of a hybrid classifier that exploits both transfer learning and semi-supervised paradigms in order to maintain good generalization accuracy, especially when li ...STTR Phase I 2018 Department of DefenseNational Geospatial-Intelligence Agency
SBC: SIGNATURE RESEARCH, INC. Topic: 1
Signature Research, Inc. (SGR) and Michigan Technological University (MTU) propose a Phase I STTR effort to develop a learning algorithm which exploits the spatio-spectral characteristics inherent within IR imagery and motion imagery.Our archive of modelled and labeled data sets will allow our team to thoroughly capture the variable elements that will drive machine learning performance.The overall ...STTR Phase I 2018 Department of DefenseNational Geospatial-Intelligence Agency