Award Data

DESCRIPTION (provided by applicant): The overall objective of the proposed work is to reduce the cost of accelerator produced F-18 radiopharmaceuticals used in Positron Emission Tomography (PET), a Medicare-reimbursed nuclear medicine metabolic imaging modality used to diagnose, stage, and restage ten cancer indications. Annual PET scans (350,000+) are rapidly increasing, but CMS reimbursement ...

DESCRIPTION (provided by applicant): With its ability to secrete high levels of recombinant proteins, the yeast Pichia pastoris is extensively used for protein manufacturing. However, as actual yields vary widely for individual proteins, GlycoFi is focusing on the improvement of protein yields in P. pastoris as part of the company's long term mission to develop yeast-based protein production tech ...

DESCRIPTION (provided by applicant): It has been estimated that 90% of all eye injuries could have been avoided if proper safety eyewear had been used. Despite widespread required use of safety eyewear in the work place, there continues to be a significant reluctance among workers to comply because of discomfort and the inability to see clearly due to scratches. Commercially available scratch resi ...

This proposal outlines the final steps in achieving the successful commercial qualification of the Tribo-Glide? high performance non-silicone lubricant system developed in Phase I and Phase II for syringes and medical devices. Achievement of regulatory approval of the non-silicone lubricant system applied to disposable glass-clear COG syringes will open the door for numerous drug companies to inco ...

PHOSPHO-ENERGETICS, INC. (P-E) HAS DEVELOPED AN NMR SPECTRO-METER FOR THE VALIDATION OF 31P IN DISEASED AND NORMAL HUMANTISSUES; BASED UPON THAT PROCESS, P-E HAS NOW DEVELOPED A COMBINATION NMR/WORK OUTPUT MEASURING INSTRUMENT. STUDIES HAVE BEEN PERFORMED WITH SUBJECTS SUFFERING FROM PERIPHERAL VASCULAR DISEASE, GENETIC DEFECTS, AND CARDIOMYOPATHY, AS WELL AS NORMAL VOLUNTEERS AND ATHLETES LEADING ...

DESCRIPTION (provided by applicant): In response to published NIDA research topics calling for innovation in educational programs aimed at substance abuse prevention, the proposed project will develop and empirically tested media literacy alcohol and tobacco use prevention curriculum with use with children in grades three through five. The curriculum will contain goals, lesson plan scripts and act ...

DESCRIPTION (provided by applicant): A vast number of novel proteins discovered from genome sequencing projects are creating enormous opportunities for scientists in academia and industry. Large-scale consortia and initiatives are underway to understand the structures of newly discovered proteins. Unfortunately, protein expression and purification are a major bottleneck. Bacteria are usually th ...

The long-term goal of this research is to develop a drug that is safe and effective against drug-resistant human immunodeficiency virus (HIV) infection. Several challenges confront current anti-HIV chemotherapy. The frequency of drug-resistant and multidrug-resistant HIV-1 is increasing. Toxicities associated with current HIV medications often result in the discontinuation of these therapies. Phys ...

THE LONG-TERM RESEARCH OBJECTIVE IS TO MAKE COMMERCIALLY AVAILABLE A MICROCOMPUTER-BASED SYSTEM TO FACILITATE PATIENT SELF-CONTROL OF INSULIN DEPENDENT DIABETES MELLITUS. THIS COMPREHENSIVE ""DIABETES IN SELF-CONTROL (DISC) SYSTEM'' IS COMPOSED OF: 1.AN INSTRUCTIONAL AND REINFORCEMENT COMPONENT FOR COMPUTER ASSISTED HOME BLOOD GLUCOSE MONITORING; 2.A COMPONENT WHICH PROVIDES COMPUTER ASSISTED INST ...

DESCRIPTION (PROVIDED BY APPLICANT): Schizophrenia affects roughly 1% of the world's population, with more than two million Americans afflicted in any given year, and an estimated 30-50 million people worldwide. Treatment with available antipsychotic medications often effectively attenuates the positive symptoms of schizophrenia without improvement in the negative symptoms or cognitive deficits. F ...