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PROJECTSUMMARY Scaling extracellular electrophysiology to higher channel counts is hindered by the burden of data handling storageand especially preprocessinge gspike sortingThe burden of spike sorting can in principle be reduced through a combination of high density multielectrode arrayprobetechnology and algorithm optimization to yield a spike sorting method that is both highly accurate and full ...

AbstractTransition age youthTAYfrom agesare especially vulnerable to substance usemisuseand substance use disorderSUDThis developmental periodtermed theage of instabilityandquotand andquot emerging adulthoodandquotincludes tasks such as leaving homeentering collegeidentifying vocational goalsworking for the first timebody and sexuality changescoalescing with a peer groupand for someaging out of fo ...

Project Summary AbstractThe United States alcoholic beverage market topped $Billion inselling enough alcohol for each American to consumelitersgallonsof pure alcohol inDue to alcohol consumptionandapos s long history and ample financial interestthere has been a great deal of research around alcohol and the benefits and detriments to consuming itDespite the commonality of alcohol consumption and th ...

While biological models of mental illness once emphasized “chemical imbalances,” modern perspectives increasingly incorporate a more nuanced understanding of genetics and epigenetics, neurotransmitters and neuroplasticity, and the functional dynamics of neural circuits. Yet despite extraordinary advances in neuroscience that have dramatically enhanced our understanding of the brain and of the ...

TBD

Project Summary Abstract Sepsis kills more thanAmericans annuallyNo approved drugs are available and overdrug candidates failed late stage clinical trialswhich highlights the urgent need for novel approachesThe longterm goal of this project is to develop a new mechanism basedefficient and low toxicity sepsis therapyTriggering receptor expressed on myeloid cellsTREMan inflammation amplifieris overe ...

Triple negative breast cancersTNBCsaccount forof breast cancer deaths and lack targeted therapiesWe identified the non essentialcell surface protein ADAMas an important target on TNBCADAMis present inof primary TNBCsandof all breast cancer patient derived metastasesbut absent in normal breast tissuesHigh ADAMmRNA levels correlate with poor patient outcomeThe ADAMMetalloproteinaseMPand DisintegrinD ...

PROJECT SUMMARY Pain management is a significant unmet medical needPalmitoylethanolamidePEAis an endogenous analgesic substance that plays crucial roles in the peripheral control of pain and inflammationIts biological actions are terminated by the cysteine hydrolaseN acylethanolamine acid amidaseNAAADuring the Phaseof the present SBIRapplicationwe have developed the first class of potentselective ...

ABSTRACTTo datemore thanmicroRNAsmiRshave been identified in humansAberrant miRs expression has been associated with many human diseasesand especially with cancerThereforeearly detection and quantitation of those miRs can have a significant impact on patientsandaposoutcome and survival rateThe utility of miRs as potential clinical and diagnostic tools is severely limited by the availability of sim ...

The proposed Phase II SBIR project will develop a unique motor unit (MU) based control system (MU Drive™) that uses neural firings measured noninvasively and in real-time to drive an upper-limb prosthesis. Our Phase I effort successfully proved the technical merit and feasibility by demonstrating that MU firings can be measured from surface myoelectric recordings in real-time and used to provide ...