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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. FLOW CYTOMETRY-IMPROVING COST-EFFECTIVENESS

    SBC: HOWARD M. SHAPIRO, MD, P.C.            Topic: N/A

    FLOW CYTOMETRY IS USED FOR THE COUNTING, SIZING AND BIO- CHEMICAL CHARACTERIZATION OF SINGLE CELLS AND HAS BECOME INCREASINGLY IMPORTANT IN CELL BIOLOGY IN GENERAL AND IN STUDIES OF CELLULAR IMMUNITY AND CANCER IN PARTICULAR. THE COMPLEXITY AND COST OF THE MOST MODERN APPARATUS HAVE RESTRICTED THE RANGE OF EXPERIMENTAL AND CLINICAL APPLICA- TIONS OF THE TECHNIQUE. A NEW INSTRUMENT DESIGN THAT EMPL ...

    SBIR Phase II 1988 Department of Health and Human Services
  2. SPECIFIC ANTIBODIES TO HUMAN AND ANIMAL POLYOMA VIRUS TUMOR

    SBC: Integrated Genetics Inc            Topic: N/A

    BK VIRUS (BKV), A PAPOVAVIRUS THAT IS HIGHLY PREVALENT IN THE HUMAN POPULATION, IS RELATED TO AND SHARES SOME ANTIGENIC AND BIOCHEMICAL PROPERTIES WITH THE BETTER- CHARACTERIZED SIMIAN VIRUS SV40. INFECTION WITH BKV LEADS TO THE PRODUCTION OF TUMOR OR T-ANTIGENS, WHICH, IN THE CASEOF SV40, HAVE BEEN SHOWN TO PLAY A CENTRAL ROLE IN THE ONCOGENICITY OF THE VIRUS. WHILE THE ABILITY OF BKV TO INFECT H ...

    SBIR Phase II 1988 Department of Health and Human Services
  3. RAPID DIAGNOSTIC TEST FOR HUMAN FUNGAL PATHOGENS

    SBC: Integrated Genetics Inc            Topic: N/A

    LOCALIZED AND SYSTEMIC MYCOSES CAUSED BY PATHOGENIC FUNGI (E.G., THE YEASTS CANDIDA ALBICANS AND CRYPTOCOCCUS NEOFORMANS) REPRESENT A SERIOUS HEALTH THREAT, ESPECIALLY TOIMMUNOCOMPROMISED PATIENTS AMONG WHOM INVASIVE CANDIDIASIS HAS HIGH MORBIDITY AND MORTALITY. CURRENTLY, IDENTIFICATIONOF FUNGAL PATHOGENS REQUIRES ISOLATION OF PURE CULTURES, FOLLOWED BY TESTING FOR SUBSTRATE ASSIMILATION AND FERM ...

    SBIR Phase II 1988 Department of Health and Human Services
  4. MULTIDRUG-RESISTANCE PATTERSN IN HUMAN TUMOR CELLS

    SBC: Integrated Genetics Inc            Topic: N/A

    NEW ANTITUMOR COMPOUNDS IDENTIFIED IN SCREENING PROGRAMS AREFREQUENTLY INEFFECTIVE AGAINST METASTATIC HUMAN TUMORS THAT EXHIBIT MULTIPLE-DRUG RESISTANCE. TO ENHANCE THE EFFICIENCYOF SCREENING FOR AGENTS LIKELY TO BE EFFECTIVE IN THE TREATMENT OF SUCH TUMORS, INTEGRATED GENETICS, INC. PROPOSESTO DEVELOP A DIAGNOSTIC PRODUCT CONSISTING OF A PANEL OF WELL-CHARACTERIZED, MULTIDRUG-RESISTANT DERIVATIVE ...

    SBIR Phase II 1988 Department of Health and Human Services
  5. PRODUCTION OF A HORMONE RECEPTOR COMPETITIVE ANTAGONIST

    SBC: Integrated Genetics Inc            Topic: N/A

    RECENT RESEARCH IN REPRODUCTIVE ENDOCRINOLOGY HAS DEMONSTRATED THE IMPORTANCE OF FOLLICLE STIMULATING HORMONE (FSH) IN THE REGULATION OF GAMETOGENESIS AND GONADAL STEROIDPRODUCTION. IT HAS BEEN SHOWN THAT N-LINKED OLIGOSACCHARIDES, ATTACHED TO ASPARAGINE RESIDUES AT SPECIFIC SITES ALONG THE MOLECULE, ARE ESSENTIAL FOR POST-RECEPTOR TARGET CELL ACTIVATION BUT NOT RECEPTOR BINDING. THESE SUGARS ALSO ...

    SBIR Phase I 1988 Department of Health and Human Services
  6. AUTOMATED LARGE SCALE ANALYSIS OF HUMAN COSMID LIBRARIES

    SBC: Integrated Genetics Inc            Topic: N/A

    THE OBJECTIVE OF THE PROPOSED RESEARCH PLAN IS TO DEVELOP METHODS TO RAPIDLY SCREEN, ISOLATE, AND CHARACTERIZE COSMID CLONES FROM HUMAN DNA LIBRARIES. IN PHASE I WE WILL ESTABLISH PROCEDURES FOR USING A ROBOTIC WORKSTATION TO AUTOMATE THE SCREENING OF A COSMID LIBRARY PREPARED FROM A SOMATIC CELL HYBRID THAT CONTAINS HUMAN CHROMOSOME 21. WE WILL ALSO OPTIMIZE THE USE OF AN INSTRUMENT THAT CAN DIRE ...

    SBIR Phase I 1988 Department of Health and Human Services
  7. CHROMOSOME SIGNPOSTS FOR GENE MAPPING

    SBC: Integrated Genetics Inc            Topic: N/A

    THE LONG-TERM GOAL IS TO CLONE A SET OF DNA MARKERS SPACED EVERY 5 CENTIMORGANS ALONG THE HUMAN GENOME. TO ACHIEVE THIS GOAL, A NOVEL APPROACH HAS BEEN DEVISED TO GENERATE A SET OF NATURALLY SPACED CHROMOSOMAL SIGNPOSTS. THESE SIGNPOSTS WILL ALLOW RAPID CHROMOSOME ASSIGNMENT AND REGIONAL LOCALIZATION OF UNMAPPED SEQUENCES AND GENES. FUTHERMORE, IT IS BELIEVED THAT THIS STRATEGY WILL FACILITATE ORD ...

    SBIR Phase I 1988 Department of Health and Human Services
  8. INTERPHASE CYTOGENETICS: CHROMOSOME SPECIFIC DNA PROBES

    SBC: Integrated Genetics Inc            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  9. IMPROVED INFANT NUTRITIONAL FORMULATIONS

    SBC: Lipid Specialties Inc            Topic: N/A

    IT HAS BEEN SHOWN THAT LONG CHAIN POLYUNSATURATED ESSENTIAL FATTY ACIDS SUCH AS GAMMA LINOLENIC ACID (GLA), EICOSAPENTAENOIC ACID (EPA), AND DOCOSAHEXAENOIC ACID (DHA) ARE PRESENT IN VERY HIGH CONCENTRATIONS IN HUMAN BREAST MILK. IN DEVELOPING NEW AND IMPROVED INFANT FORMULAS, THERENOW APPEARS TO BE A CRITICAL NEED FOR INCLUSION OF GLA, EPA,AND DHA AS NUTRIENTS FOR THE NEONATE. HOWEVER, TO DO SO O ...

    SBIR Phase I 1988 Department of Health and Human Services
  10. DIGITAL MAMMOGRAPHY FOR STEREOTACTIC NEEDLE PLACEMENT

    SBC: Lorad Corpon            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services

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