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LOCALIZED AND SYSTEMIC MYCOSES CAUSED BY PATHOGENIC FUNGI (E.G., THE YEASTS CANDIDA ALBICANS AND CRYPTOCOCCUS NEOFORMANS) REPRESENT A SERIOUS HEALTH THREAT, ESPECIALLY TOIMMUNOCOMPROMISED PATIENTS AMONG WHOM INVASIVE CANDIDIASIS HAS HIGH MORBIDITY AND MORTALITY. CURRENTLY, IDENTIFICATIONOF FUNGAL PATHOGENS REQUIRES ISOLATION OF PURE CULTURES, FOLLOWED BY TESTING FOR SUBSTRATE ASSIMILATION AND FERM ...

NEW ANTITUMOR COMPOUNDS IDENTIFIED IN SCREENING PROGRAMS AREFREQUENTLY INEFFECTIVE AGAINST METASTATIC HUMAN TUMORS THAT EXHIBIT MULTIPLE-DRUG RESISTANCE. TO ENHANCE THE EFFICIENCYOF SCREENING FOR AGENTS LIKELY TO BE EFFECTIVE IN THE TREATMENT OF SUCH TUMORS, INTEGRATED GENETICS, INC. PROPOSESTO DEVELOP A DIAGNOSTIC PRODUCT CONSISTING OF A PANEL OF WELL-CHARACTERIZED, MULTIDRUG-RESISTANT DERIVATIVE ...

RECENT RESEARCH IN REPRODUCTIVE ENDOCRINOLOGY HAS DEMONSTRATED THE IMPORTANCE OF FOLLICLE STIMULATING HORMONE (FSH) IN THE REGULATION OF GAMETOGENESIS AND GONADAL STEROIDPRODUCTION. IT HAS BEEN SHOWN THAT N-LINKED OLIGOSACCHARIDES, ATTACHED TO ASPARAGINE RESIDUES AT SPECIFIC SITES ALONG THE MOLECULE, ARE ESSENTIAL FOR POST-RECEPTOR TARGET CELL ACTIVATION BUT NOT RECEPTOR BINDING. THESE SUGARS ALSO ...

THE OBJECTIVE OF THE PROPOSED RESEARCH PLAN IS TO DEVELOP METHODS TO RAPIDLY SCREEN, ISOLATE, AND CHARACTERIZE COSMID CLONES FROM HUMAN DNA LIBRARIES. IN PHASE I WE WILL ESTABLISH PROCEDURES FOR USING A ROBOTIC WORKSTATION TO AUTOMATE THE SCREENING OF A COSMID LIBRARY PREPARED FROM A SOMATIC CELL HYBRID THAT CONTAINS HUMAN CHROMOSOME 21. WE WILL ALSO OPTIMIZE THE USE OF AN INSTRUMENT THAT CAN DIRE ...

THE LONG-TERM GOAL IS TO CLONE A SET OF DNA MARKERS SPACED EVERY 5 CENTIMORGANS ALONG THE HUMAN GENOME. TO ACHIEVE THIS GOAL, A NOVEL APPROACH HAS BEEN DEVISED TO GENERATE A SET OF NATURALLY SPACED CHROMOSOMAL SIGNPOSTS. THESE SIGNPOSTS WILL ALLOW RAPID CHROMOSOME ASSIGNMENT AND REGIONAL LOCALIZATION OF UNMAPPED SEQUENCES AND GENES. FUTHERMORE, IT IS BELIEVED THAT THIS STRATEGY WILL FACILITATE ORD ...

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IT HAS BEEN SHOWN THAT LONG CHAIN POLYUNSATURATED ESSENTIAL FATTY ACIDS SUCH AS GAMMA LINOLENIC ACID (GLA), EICOSAPENTAENOIC ACID (EPA), AND DOCOSAHEXAENOIC ACID (DHA) ARE PRESENT IN VERY HIGH CONCENTRATIONS IN HUMAN BREAST MILK. IN DEVELOPING NEW AND IMPROVED INFANT FORMULAS, THERENOW APPEARS TO BE A CRITICAL NEED FOR INCLUSION OF GLA, EPA,AND DHA AS NUTRIENTS FOR THE NEONATE. HOWEVER, TO DO SO O ...

CURRENT DRUG THERAPY FOR HYPERCALCEMIC DISEASES INVOLVING BONE RESORPTION IS OF LIMITED EFFECTIVENESS. PRELIMINARY ANIMAL TESTING HAS SHOWN BENZO(B)THIOPHENE-2-CARBOXYLIC ACID(THIONAPTHENECARBOXYLIC ACID, TNCA) TO BE OF POTENTIAL USE IN INHIBITING BONE RESORPTION. OVERALL PROJECT GOALS ARE TO DEVELOP TNCA AND ITS DERIVATIVES AS NOVEL THERAPEUTIC ENTITIES IN THE TREATMENT OF HYPERCALCEMIA OF MALIGN ...

ACUTE OR CHRONIC FAILURE OF THE KIDNEYS RESULTS IN RAPID DEATH UNLESS NORMAL KIDNEY FUNCTION IS REPLACED BY DIALYSIS.DIALYSIS PURIFIES THE BLOOD IN A SELECTIVE WAY, REMOVING TOXIC SUBSTANCES VIA A SEMI-PERMEABLE MEMBRANE, OR FILTER. HEMODIALYSIS EMPLOYS AN ARTIFICIAL EXTRACORPOREAL MEMBRANE WHICH NOT ONLY RESTRICTS THE FREEDOM OF THE PATIENT, BUT IS ALSO ASSOCIATED WITH VARIOUS SIDE EFFECTS. PERIT ...

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