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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 61 - 70 of 10972 results
  1. Automatic, Opportunistic Surveillance of Hip Bone Fragility in X-ray Images

    SBC: BIOSENSICS LLC            Topic: NIA

    PROJECT SUMMARY / ABSTRACTApproximately 1 in 3 women and 1 in 5 men over the age of 50 will suffer from a fragility fracture in their remaining lifetime. Fragility hip fracture is one of the most serious and debilitating outcomes of osteoporosis with a 20–40% mortality rate during the first year after the fracture. Hip fracture incidence rates are known to increase exponentially with age in both ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Development of an ELISA for serosurveillance of human hookworm

    SBC: KEPHERA DIAGNOSTICS LLC            Topic: NIAID

    Hookworm infection, caused by Necator americanus, Ancylostoma duodenale, and Ancylostoma ceylanicum is a leading cause of malnutrition and stunted growth in poor communities across sub-Saharan Africa, Asia, and parts of South America. Recent studies have revealed the re-emergence of this parasite in the USA. The burden of hookworm infection is generally associated with chronic illness rather than ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Auto-Titrating Oral Appliance for Sleep Disordered Breathing

    SBC: RUSH RIVER RESEARCH CORP            Topic: NHLBI

    Project Summary/Abstract Rush River Research Corp. (RRR) proposes to develop an auto-titrating oral appliance that fits fully-in-the-mouth for Sleep Disordered Breathing (SDB) therapy. SDB, resulting from airway obstruction, is directly linked to the four most costly diseases in the United States: heart disease, diabetes, obesity, and cancer. Research has shown that SBD sufferers are three times m ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. IND-enabling studies of an intranasal, single-replication M2SR influenza vaccine

    SBC: FLUGEN INC            Topic: NIAID

    ABSTRACT Influenza (flu) virus, an NIAID category C priority pathogen, causes a respiratory disease resulting in over 200,000 hospitalizations and ~ 36,000 deaths per year in the US, while global influenza pandemics have resulted in as many as 50-100 million deaths worldwide. To address this threat to public health, annual vaccination is recommended for all individuals aged over 6 months in the US ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Cell Culture Inserts and 3D In Vitro Tissue Models Utilizing Novel Electrospun Scaffolds

    SBC: BIOSURFACES INC            Topic: R

    Tissue culture inserts that utilize film-based microporous membrane scaffolds are key components of in vitro tissue models that are used as alternatives to animal testing. However, insert scaffold technology has not significantly advanced in nearly 30 years. Currently available film-based insert scaffolds are only 2-dimensional (2D), and are excessively rigid compared to natural extracellular matr ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Developing a blood fatty acid-based algorithm as an early predictor of insulin resistance: Applying machine learning to harmonized data from prospective cohort studies

    SBC: OMEGAQUANT ANALYTICS, LLC.            Topic: 200

    Project Summary Metabolic diseases, such as Metabolic Syndrome (MetSyn) and type 2 diabetes (T2DM) affect ~37% and ~10% of Americans, respectively, with a substantial impact on the health, quality of life and financial security of these individuals. Without the means to identify high risk individuals conveniently and cheaply, many will find care too little and too late: more than 80% of individual ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Evaluation of photoreceptors health and function in diabetic retinopathy patients using a high-resolution retinal imaging device with controlled light stimulus

    SBC: PHYSICAL SCIENCES INC.            Topic: 100

    Project Summary/AbstractPhysical Sciences Inc (PSI), in collaboration with Joslin Diabetes Center (JDC), proposes to enable objective characterization of the photoreceptor response to light and thus quantification of differences between normal and diseased eyes by adding controlled light stimulus capabilities to an existing high-resolution retinal imaging platform and validating it on a group of v ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Machine learning optimized autoimmune therapeutics with a focus on Type 1 Diabetes

    SBC: THINK THERAPEUTICS, INC.            Topic: NIAID

    Project Summary We propose to develop a new immunogenicity assay and machine learning based framework for creating tolerization vaccines for autoimmune diseases with improved population coverage. In collaboration with Harvard University and the University of Massachusetts Chan Medical School Diabetes Center of Excellence we will develop a new assay, the Multiplexed Multi-antigen Activation Assay ( ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Fast Field Screening of PFAS in Non-Portable Waters..

    SBC: 2witech Solutions LLC            Topic: NIEHS

    Project Summary/Abstract: 2Witech Solutions LLC proposes a Phase I Small Business Innovation Research project to develop a portable electrochemical sensing device for quick field screening of trace PFAS in non-potable waters (groundwater, surface water, and wastewater) by combining its recent achievement in molecular- imprinting technology and electrochemical sensor development. The overall object ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Enhancing detection and mobile monitoring of schistosomiasis with urine-based analyte pre-concentration technology

    SBC: SALUS DISCOVERY LLC            Topic: NIAID

    ABSTRACT Schistosomiasis is a debilitating parasitic disease that infects over 230 million people and causes 280,000 deaths per year. New estimates of global disease burden rank schistosomiasis as the third most impactful infectious disease behind only HIV/AIDS and malaria. Therefore, over the past decade, global health organizations have renewed interest in schistosomiasis control and elimination ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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