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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 61 - 70 of 22622 results
  1. Rapid Test for Recent HIV Infection

    SBC: IMMUNETICS, INC.            Topic: R

    DESCRIPTION provided by applicant Monitoring the HIV epidemic to understand rates and patterns of growth as well as targeting intervention efforts to populations exhibiting high rates f HIV transmission are wholly dependent on determining the frequency of new infections using an assay that discriminates recent from long term HIV infection However very few HIV assays have been developed spec ...

    SBIR Phase II 2014 Department of Health and Human Services
  2. Novel spectinamide antibiotics for the treatment of MDR/XDR tuberculosis

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The overall objective of this project is to develop a novel chemical class of tuberculosis TB therapeutic agents the spectinamide series for use against MDR and XDR strains of Mycobacterium tuberculosis Mtb and identify through a series of in vivo efficacy assays and preclinical pharmacokinetics toxicology and safety pharmacology studies a clinical can ...

    SBIR Phase II 2014 Department of Health and Human Services
  3. Drug Discovery from Slow Growing and Rare Microbial Species

    SBC: NOVOBIOTIC PHARMACEUTICALS, LLC            Topic: NIAID

    DESCRIPTION provided by applicant The overall goal of this project is to discover novel antibiotics to combat important drug resistant pathogens We are running out of treatment options for pathogens such as S aureus MRSA vancomycin resistant Enterococci VRE multidrug resistant P aeruginosa A baumannii ESBL and New Delhi metallo b lactamase producing Enterobacteriaceae and M tuberculosis Only novel ...

    SBIR Phase II 2013 Department of Health and Human Services
  4. Rapid, Near-Tranfusion Test for Bacteria in Platelets Units

    SBC: IMMUNETICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Bacterial contamination of platelets is considered the greatest infectious risk of blood product transfusion today at about 1 in 2000 platelet units, which is several orders of magnitude greater than that of HIV. Bacterial contamination at high levels can lead to severe morbidity or mortality in transfusion recipients. The American Association of Blood Banks is ...

    SBIR Phase II 2013 Department of Health and Human Services
  5. Catheter Guidance System for RF Ablation of Arrhythmias

    SBC: Infoscitex Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Building on the accomplishments of the prior Phase I and Phase II NIH SBIR grants in which Infoscitex was the lead institution and MIT was the subcontractor, in this Phase II competitive renewal grant application we propose to develop a commercial quality catheter guidance system that will allow clinicians to treat ventricular tachycardia (VT) with radio freque ...

    SBIR Phase II 2009 Department of Health and Human Services
  6. Novel Diagnostic Sequencing System for HIV Resistance Testing

    SBC: INTELLIGENT BIO-SYSTEMS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): As of 2008 the CDC estimated that there were approximately 1.1 million persons in the U.S. infected with HIV- 1 and about 56,000 new cases are diagnosed each year. During the mid-to-late 1990s, advances in treatment slowed the progression of HIV to AIDS and related deaths. Unfortunately, the treatment often leads to the emergence of drug resistant mutants of HI ...

    SBIR Phase II 2011 Department of Health and Human Services
  7. Closed-Loop Wireless Optical Neuromodulation for Motion Disorders

    SBC: FERRO SOLUTIONS, INC.            Topic: NINDS

    DESCRIPTION provided by applicant Optogenetic tools for activating and silencing specific neurons embedded within dense brain networks in a temporally precise fashion using light are key to understanding the roles that specific neurons play in behavior neural computation and disease In our Phase I SBIR Ferro Solutions and the Boyden lab at MIT collaborated to develop a fully wirelessly powered and ...

    SBIR Phase II 2013 Department of Health and Human Services
  8. Identification of Novel Broad Spectrum Influenza Virus Inhibitors

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Our goal is to develop small molecule inhibitors that target influenza entry. In Phase I, we identified several compounds that selectively inhibit the hemagglutinin (HA) mediated virus entry process. Three HA specific entry inhibitors (MBX494, MBX994, and MBX726) were selected for further research and development based on their antiviral potency, selectivity an ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. Rapid sensitive low-cost test for resistant microbes causing hospital infections

    SBC: FIRST LIGHT BIOSCIENCES, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): We propose to develop a novel automated platform to enable rapid, sensitive, user-friendly, and cost-effective screening for the antibiotic resistant bacteria that frequently cause serious healthcare associated infections. Every year, about 100,000 deaths result from 2 million serious healthcare associated infections at an estimated cost of 35B. About 20,000 f ...

    SBIR Phase II 2011 Department of Health and Human Services
  10. Development and Performance Evaluation of a Handheld Noninvasive Glucose Monitor

    SBC: VIVASCAN CORPORATION            Topic: N/A

    Location 100 Grove Street Suite 315 Worcester, MA 01605 United States See map: Google Maps 2R44DK059088-04 $2 892 330.00 2 008 Development and Performance Evaluation of a Handheld Noninvasive Glucose Monitor Department of Health and Human Services SBIR Y ...

    SBIR Phase II 2008 Department of Health and Human Services

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