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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Early detection and monitoring of Alzheimers Disease and Related Dementias using non-semantic linguistic and acoustic features of speech derived from hearing aids

    SBC: BISCHOFF HOLDINGS INC            Topic: NIA

    Abstract Alzheimer’s disease and related dementias (ADRD) are a serious national health concern that affected 5.8 million in 2020 and are expected to increase by 40% over the next decade. There is evidence that the functional, psychological, pathological, and physiological changes underlying ADRD may emerge many years prior to the clinical manifestation of cognitive symptoms, which is increasing ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 433: A FEDERATED DATA PLATFORM FOR DEVELOPING UNBIASED BREAST IMAGING AI

    SBC: FLYWHEEL EXCHANGE, LLC            Topic: 433

    This SBIR project aims to implement a federated data platform focused on a data system to enable mammography data to be published into a federated catalog from which collaborators can execute federated analyses. It will enable hospitals and other clinical entities to make their data available for training and validation of artificial intelligence applications. The data federation will include a ra ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  3. DEVELOPING A NOVEL NON-VIRAL NANOPIECES GENE DELIVERY SYSTEM FOR AD GENE THERAPY

    SBC: Nanode Therapeutics, Inc.            Topic: 4

    To develop a new, safe, and efficacious non-viral gene delivery system crossing the blood-brain barrier (BBB) for gene therapy of Alzheimer’s Disease (AD).

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Pilot Clinical Study to Assess Safety and Efficacy of External Ventricular Drainage with Cerebrospinal Fluid Water Removal Osmotherapy for Traumatic Brain Injury-Induced Cerebral Edema

    SBC: CEROVATIONS LLC            Topic: 106

    Project Summary Significance: Cerebral edema develops in a large percentage of severe traumatic brain injury (TBI) cases and may lead to worsened morbidity. The importance of osmotic gradients as the cause of edema has been described. Published reports indicate cerebral edema remains refractory in many patients to all currently available treatments. Translational research has identified reversal o ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Portable Noninvasive Positive Airway Device for COPD Patient Therapy

    SBC: Koronis Biomedical Technologies Corp.            Topic: NHLBI

    Abstract Koronis Biomedical Technologies proposes to develop and fully evaluate a novel, on-demand handheld bi-level positive airway pressure (BiPAP) ventilator to treat Chronic Obstructive Pulmonary Disease (COPD) patients suffering from exertional dyspnea (“breathlessness”). It is well known that dyspnea trends severe COPD patients as they age towards inactivity, resulting in peripheral musc ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Clinical Decision Support for Assessing Pulmonary Embolism using Machine Learning

    SBC: Minnesota HealthSolutions Corporation            Topic: NHLBI

    Project Summary/Abstract Minnesota HealthSolutions (MHS) proposes a Phase II project to develop and validate a software product capable of automatically detecting and staging pulmonary embolisms (PEs) using clinically routine pulmonary CT angiograms (CTAs). The proposed system will combine state-of-the-art machine learning methods and the clinical expertise at Duke University into a system that in ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. A Lifestyle Program for Comorbid Obstructive Sleep Apnea with Severy Obesity

    SBC: Minnesota HealthSolutions Corporation            Topic: NHLBI

    Project Summary/Abstract Minnesota HealthSolutions Corporation in collaboration with the Mayo Clinic proposes to develop a data driven system for persons with obesity sleep apnea that utilizes remote monitoring together with health coaching to create behavior change aimed at improving health and quality of life. Obstructive sleep apnea prevalence has been estimated at 7% for adult males and 5% for ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. A non-viral gene editing platform for cell therapies and translational autoimmune disease modeling

    SBC: LifEngine Animal Health Laboratories Incorporated            Topic: 100

    SUMMARY Gene edited T lymphocytes hold promise as safe and effective living therapies for a wide range of human diseases, including autoimmune disease. However, viral methods currently employed to engineer cells for therapy are imprecise, exorbitantly expensive, and have high failure rates. These drawbacks limit development of cell therapies and prevent them from penetrating alternative markets, w ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Modular Convertible Child Safety Seat to Improve Usage

    SBC: Minnesota HealthSolutions Corporation            Topic: NICHD

    Project Summary/Abstract Minnesota HealthSolutions Corporation proposes to develop an innovative all-new convertible child safety seat. Child safety seats are installed in vehicles by properly attaching and tensioning the main anchorage points. Proper use of the attachments is extremely important as these significantly reduce child head injuries in motor vehicle crashes. Attachments are inconvenie ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. ToxIndex-CPG: Machine learning driven platform integrating a hazard susceptibility database to quantify chemical toxicity factors, predict risk levels and classify biological responses

    SBC: INSILICA LLC            Topic: R

    The overall global market for toxicology testing was $8.1 billion in 2019 and is expected to reach $27 billion by 2025. As toxicological testing is a pre-requisite step in most product development, it adds significant time and costs, as well as represents human health hazards when key data is not captured. In order to minimize time to market, expense, and animal use, advances in computational biol ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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