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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Pilot Clinical Study to Assess Safety and Efficacy of External Ventricular Drainage with Cerebrospinal Fluid Water Removal Osmotherapy for Traumatic Brain Injury-Induced Cerebral Edema

    SBC: CEROVATIONS LLC            Topic: 106

    Project Summary Significance: Cerebral edema develops in a large percentage of severe traumatic brain injury (TBI) cases and may lead to worsened morbidity. The importance of osmotic gradients as the cause of edema has been described. Published reports indicate cerebral edema remains refractory in many patients to all currently available treatments. Translational research has identified reversal o ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Portable Noninvasive Positive Airway Device for COPD Patient Therapy

    SBC: Koronis Biomedical Technologies Corp.            Topic: NHLBI

    Abstract Koronis Biomedical Technologies proposes to develop and fully evaluate a novel, on-demand handheld bi-level positive airway pressure (BiPAP) ventilator to treat Chronic Obstructive Pulmonary Disease (COPD) patients suffering from exertional dyspnea (“breathlessness”). It is well known that dyspnea trends severe COPD patients as they age towards inactivity, resulting in peripheral musc ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Clinical Decision Support for Assessing Pulmonary Embolism using Machine Learning

    SBC: Minnesota HealthSolutions Corporation            Topic: NHLBI

    Project Summary/Abstract Minnesota HealthSolutions (MHS) proposes a Phase II project to develop and validate a software product capable of automatically detecting and staging pulmonary embolisms (PEs) using clinically routine pulmonary CT angiograms (CTAs). The proposed system will combine state-of-the-art machine learning methods and the clinical expertise at Duke University into a system that in ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  4. A Lifestyle Program for Comorbid Obstructive Sleep Apnea with Severy Obesity

    SBC: Minnesota HealthSolutions Corporation            Topic: NHLBI

    Project Summary/Abstract Minnesota HealthSolutions Corporation in collaboration with the Mayo Clinic proposes to develop a data driven system for persons with obesity sleep apnea that utilizes remote monitoring together with health coaching to create behavior change aimed at improving health and quality of life. Obstructive sleep apnea prevalence has been estimated at 7% for adult males and 5% for ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. A non-viral gene editing platform for cell therapies and translational autoimmune disease modeling

    SBC: LifEngine Animal Health Laboratories Incorporated            Topic: 100

    SUMMARY Gene edited T lymphocytes hold promise as safe and effective living therapies for a wide range of human diseases, including autoimmune disease. However, viral methods currently employed to engineer cells for therapy are imprecise, exorbitantly expensive, and have high failure rates. These drawbacks limit development of cell therapies and prevent them from penetrating alternative markets, w ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Modular Convertible Child Safety Seat to Improve Usage

    SBC: Minnesota HealthSolutions Corporation            Topic: NICHD

    Project Summary/Abstract Minnesota HealthSolutions Corporation proposes to develop an innovative all-new convertible child safety seat. Child safety seats are installed in vehicles by properly attaching and tensioning the main anchorage points. Proper use of the attachments is extremely important as these significantly reduce child head injuries in motor vehicle crashes. Attachments are inconvenie ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. ToxIndex-CPG: Machine learning driven platform integrating a hazard susceptibility database to quantify chemical toxicity factors, predict risk levels and classify biological responses

    SBC: INSILICA LLC            Topic: R

    The overall global market for toxicology testing was $8.1 billion in 2019 and is expected to reach $27 billion by 2025. As toxicological testing is a pre-requisite step in most product development, it adds significant time and costs, as well as represents human health hazards when key data is not captured. In order to minimize time to market, expense, and animal use, advances in computational biol ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Novel Myofunctional Therapy Water Bottle to Reduce Obstructive Sleep Apnea and Snoring

    SBC: REMASTERED SLEEP LLC            Topic: NHLBI

    Project Summary: There is a clear unmet need to provide alternative, first-line solutions for both obstructive sleep apnea (OSA) and primary snoring. Most people suffering from OSA are currently not receiving treatment with estimates of 80% undiagnosed (23 million Americans) and 40% non-adherence to the gold standard treatment, continuous positive air pressure among diagnosed patients. This has se ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Technology Assisted Treatment for Trichotillomania

    SBC: HABITAWARE, INC.            Topic: 102

    Abstract Significance: Trichotillomania (TTM), characterized by repeated pulling of one’s hair to the point of hair loss or thinning, produces impairment in physical, social, psychological and occupational functioning. While evidenced-based treatments (EBTs, i.e. self-monitoring, stimulus control, and Habit Reversal Training (HRT)) do exist, access is limited due to lack of trained treatment pro ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Virtual Reality Cognitive Therapy forAlzheimer's Disease

    SBC: CLARITYTEK INC.            Topic: NIA

    ABSTRACT Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD) currently affect more than 5.8 million Americans, costing $305 billion for treatment and management in 2020 and causing poor outcomes such as loss of independence, low quality of life, and nursing home requirements. Given the scale of diminished health-related quality of life, the need for non-invasive customizable ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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