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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Prevention of Proliferative Vitreoretinopathy by HC-HA/PTX3

    SBC: TISSUETECH, INC.            Topic: W

    DESCRIPTION provided by applicant Proliferative vitreoretinopathy PVR is characterized by membranes that develop on the surface of the retina after rhegmatogenous retinal detachments RRDs Because PVR membranes exert tractional forces on the retina they are the leading cause of failure after RRD surgery Despite additional surgical interventions the visual outcome still remains poor Prev ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. NutraStem as a neuroprotectant: Implications for neurogenesis in HAART treated patients

    SBC: NATURA THERAPEUTICS, INC.            Topic: 213

    DESCRIPTION provided by applicant We designed an experiment to understand the interactions between loss of development of new neurons neurogenesis in the brain HIV Tat protein and the known cognitive side effects imparted by chronic highly active antiretroviral therapy HAART We preliminarily found the common HAART combination for HIV patients lamivudine zidovudine efavirenz TC AZT E ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. In vitro maturation of BMP-7-responsive pancreatic beta cell progenitors by oxygen modulation technology

    SBC: Ophysio Inc.            Topic: NIDDK

    DESCRIPTION provided by applicant It is believed that emergent stem cell based therapies are destined to replace islet transplantation in the near future The first wave of next generation cell therapeutics for type diabetes T D will likely take the shape of pluripotent stem cell PSC derived pancreatic progenitors PPs that mature into insulin producing cells upon transplantation Howeve ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Jerry the Bear: A Robotic Platform for At-Home Therapy and Education for Children with Type 1 Diabetes

    SBC: Sproutel            Topic: 200

    DESCRIPTION provided by applicant The goal of this SBIR Phase I application from Sproutel is to develop a curriculum for providing expert educational content on diabetes self management to be delivered via principles of game based learning in an appealing teddy bear robotic character designed for young children diagnosed with type diabetes mellitus Type diabetes T D affects approximately ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Combination of BA-210 and digestion of the glial scar in chronic spinal cord injury

    SBC: BIOAXONE BIOSCIENCES, INC.            Topic: 102

    DESCRIPTION provided by applicant BA is an investigational drug that targets Rho an intracellular GTPase important for controlling axon regeneration and repair after spinal cord injury BA has completed a Phase I IIa clinical trial for treatment of acute spinal cord injury in patients Not only was BA safe and well tolerated but patients with cervical SCI showed very promising ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Multi-Source E-Beam kV X-Ray Tube for Image-Guided Radiotherapy

    SBC: TELESECURITY SCIENCES, INC.            Topic: 102

    DESCRIPTION provided by applicant This project will lead to the development of an optimized X ray tube with focal spots that can be placed immediately below and around the multi leaf collimator MLC of a radiotherapy system By steering a focused electron beam e beam on a series of cooled tungsten targets in sequence this system will provide a set of projection images that can be reco ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Thixotropic xylitol system (THXX) for fissure caries

    SBC: Elevate Oral Care            Topic: NIDCR

    DESCRIPTION provided by applicant Caries remains a major problem most lesions occur in fissures of permanent molars Xylitol is an effective tooth decay preventive Xylitol exerts selective antibacterial like actions against mutans streptococci MS because of its disruption of their energy metabolism and growth and reduces accumulation of MS in tooth biofilms Both ADA and AAPD recommend xyli ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Novel, Ambulatory Cuff-less Non-invasive Arterial Blood Pressure Monitor

    SBC: Krisara Engineering            Topic: NHLBI

    DESCRIPTION provided by applicant The objective of this proposal is to complete the engineering development and testing of the Non Invasive Self calibrating Ambulatory Multi Modality NISAM blood pressure device to recognize hypertensive patients not currently identified using todayandapos s technology As well as providing better management of hypertensive patients by presenting a truer roun ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Interactive anatomy-augmented virtual simulation training

    SBC: ARCHIE MD INC.            Topic: 400

    DESCRIPTION provided by applicant ArchieMD proposes to develop a series of anatomy augmented procedure training videos and interactive virtual simulation exercises to provide additional opportunities for medical simulation for nursing students without requiring an instructor Using actual video footage that has been augmented with computer generated internal anatomy combines the realism only ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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