Award Data

A Point-Of-Care Test for Rapid Diagnosis of Valley Fever PROJECT SUMMARY Coccidioidomycosis (Valley Fever) is a respiratory disease caused by inhalation of spores from the desert soil- dwelling fungus, Coccidioides spp. In endemic areas, up to 30% of community acquired pneumonia (CAP) is caused by Coccidioides spp.1 Valley Fever mimics other viral and bacterial respiratory infections and is challe ...

PROJECT SUMMARY/ABSTRACT Type 1 diabetes (T1D) is a serious multi-factorial chronic autoimmune disease with an annual 3% increase in the incidence rate that constitutes a major public health challenge and financial burden. T1D involves genetic predisposition, immune system response, and environmental factors that lead to disease initiation and progression. Due to the lack of curative therapies for ...

Perinatal brain injury resulting in mental retardation and cerebral palsy is the most severe disability in children and affects 40-148 in preterm and 1–2/1000 in full term infants. This places a huge burden on society, emphasizing the critical need for improved prevention/treatment strategies to decrease perinatal brain injury. Hypothermia (HT) is the only FDA approved therapy to attenuate brain ...

Vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease related dementias (ADRD) significantly contribute to the 47 million people world-wide who suffer with dementia. This number is estimated to increase to over 130 million people by 2050. Several studies have shown that VCID and conversion to ADRD are strongly correlated with vascular disease, inflammation an ...

Project SummaryCardiovascular disease (CVD) including stroke and myocardial infarction (MI), and Type 2 diabetes (T2D) areoverlapping global pandemics. CVD is the most common cause of death in patients with T2D and the economicburden of stroke and myocardial ischemia in patients with T2D is staggering. While newer glycemic controlagents like SGLT2 inhibitors and GLP1 agonists can help reduce CVD e ...

Necrotizing enterocolitis (NEC) is a devastating acute inflammatory condition of the gastrointestinal tract resulting in intestinal necrosis, systemic sepsis and multi-system organ failure found mostly in infants born prematurely. Despite modern medical advances in the past decade, the etiology remains elusive and morbidity and mortality are still unacceptably high. It has been concluded that the ...

Abstract: Immunophotonics is a biotech company developing a synthetic biopolymer, IP-001, to potentiate a systemic immunotherapy via microwave (MWA) thermal tumor ablation for treatment of Hepatocellular carcinoma (HCC). The goal of this SBIR Fast Track is to complete preclinical safety and efficacy testing to support an investigational new drug (IND) application based on the feedback from a meeti ...

Heatable solid-state batteries (SSBs) have the potential to enable high energy density and ultra-safe fast charging in electric vehicles (EVs) during cold weather overcoming many of the consumer acceptance barriers hindering widespread adoption. With proper material and system optimization, they are expected to reach desired charging rates of 4C or higher with 80% capacity retention at ambient tem ...

Heatable solid-state batteries (SSBs) have the potential to enable high energy density and ultra-safe fast charging in electric vehicles (EVs) during cold weather overcoming many of the consumer acceptance barriers hindering widespread adoption. With proper material and system optimization, they are expected to reach desired charging rates of 4C or higher with 80% capacity retention at ambient tem ...

"Jaia Robotics’ low-cost, micro-sized hybrid uncrewed surface/underwater vehicles called JaiaBotsTM can be deployed from the shore or vessels. The system enables truly affordable multivehicle operations that can be scaled to provide wide area synoptic data collection. In the proposed effort the project team will develop a JaiaBot which is air-deployable from sonobuoy launch tubes to collect atmo ...