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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Expression Enhanced Natural Product Pathways Using Advanced Metagenomic Tools

    SBC: LUCIGEN CORPORATION            Topic: R

    DESCRIPTION provided by applicant A post antibiotic era of multiple drug resistance has begun to threaten the health and well being of mankind A crucial limitation in economically converting untapped natural product potential to final scalable production is the lack of next generation tools to effectively access the full medicinal impact of natural environments This project utilizes innovativ ...

    SBIR Phase I 2015 Department of Health and Human Services
  2. Continuously Load-Sharing Elastically Deformable Spinal Fusion Implant

    SBC: ReVivo Medical, LLC            Topic: NIAMS

    DESCRIPTION provided by applicant ReVivo Medical LLC has developed the next generation of spinal fusion implants to help surgeons and hospitals achieve the goals of the Affordable Care Act ReVivoandapos s spinal implants are the first to leverage the basic science of bone formation to reduce time to fusion while also diminishing complication rates decreasing operating room time and loweri ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a Fully Humanized Antibody for Treating Lung Emphysema

    SBC: Emphymab Biotech            Topic: NHLBI

    DESCRIPTION provided by applicant Emphysema is a prevalent chronic obstructive pulmonary disease COPD induced predominantly by cigarette smoking is defined as the combination of chronic bronchitis in the airways and emphysema which characterized by excessive cell apoptotic cell death of alveolar lung structural cells and chronic inflammation Because alveolar structures are essential for g ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. High Energy Density, Long Life, Betavoltaic Power Cells for Pacemakers and other Implantable Devices

    SBC: Widetronix            Topic: NHLBI

    DESCRIPTION provided by applicant Pacemakers are small devices that help control abnormal heart rhythms called arrhythmia which can lead to serious life threatening conditions including organ damage cardiac arrest and death Indeed pacemakers are a highly important treatment option for cardiac arrhythmia with implanted in including in the U S growing at an annual ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Early risk assessment through mathematical modeling of quantitative placental anatomic/structural biomarkers

    SBC: Placental Analytics            Topic: NICHD

    DESCRIPTION provided by applicant Placental measures of roundness cord insertion centrality volume shape and thickness are biomarkers of maternal fetal growth Deviations from expected placental morphology even as early as weeks are related to placental dysfunction and pregnancy complications such as preeclampsia pregnancy hypertension gestational diabetes mellitus and fetal chromo ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Large Scale Synthesis of N-acetyllactosamine and Human Milk Oligosaccharides

    SBC: OMICRON BIOCHEMICALS, INC.            Topic: NICHD

    DESCRIPTION provided by applicant In this Phase I project a subset of human milk oligosaccharides HMOs ranging from disaccharides to pentasaccharides will be prepared on scales ranging from several grams to kilograms Specifically N acetyl lactosamine will be chemically prepared in kilogram quantities six HMOs will be chemically prepared on multi gram scales g and several HMOs wi ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting System Xc- for the treatment of the Autism Spectrum Disorder subpopulations, Fragile X syndrome and Phelan-McDermid syndrome

    SBC: Promentis Pharmaceuticals            Topic: NICHD

    DESCRIPTION provided by applicant Autism is the fastest growing developmental disorder in the United States with that affects about in children Thus not surprisingly the cost and burden on families patients and caregivers is enormous Associated with autism spectral disorder are other pervasive developmental disorders that include Rett syndrome Phelan McDermid syndrome and Fragile X ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. An innovative tool for assessment of gait dysfunction in the clinical setting

    SBC: METRIA INNOVATION, INCORPORATED            Topic: N

    DESCRIPTION provided by applicant The overall goal of this SBIR Phase II proposal is to develop and validate a fully commercialized instrumented gait analysis system and associated training and reporting tools Gait dysfunction can dramatically affect a personandapos s ability to perfor activities of daily living and assessment of gait is a critical component of physical therapy practice Cur ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. A new breath monitor for detection of the acute phase response in patients

    SBC: Isomark, LLC            Topic: 300

    DESCRIPTION Infections are a leading cause of mortality in adult and pediatric ICUs Earlier diagnosis and treatment of infection could significantly reduce patient morbidity and mortality Unfortunately current methods of detection cannot routinely detect infection early in the disease course Isomark has developed a breath based early detection technology biomarkers and instruments for detect ...

    SBIR Phase II 2015 Department of Health and Human Services
  10. Mini Chromosome and Fluorescent Proteins for Expression of Protein Complexes

    SBC: LUCIGEN CORPORATION            Topic: 100

    Summary abstract The proteins encoded by the human genome may participate in as many as pairwise protein interactions and nearly every major process in a cell is carried out by assemblies of or more interlocking protein molecules Bruce Alberts Cell However there are no commercially available expression systems for regulated expression of multi subunit protein complexes The ...

    SBIR Phase II 2015 Department of Health and Human Services

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