Award Data

DESCRIPTION provided by applicant This SBIR Phase I application proposes development of MedicaSafeandapos s Implicit Prescription Abuse Cognitive Toolkit IMPACT a technology enabled suite of cognitive assessment tools to significantly add to physiciansandapos ability to detect signs of opioid misuse and abuse in patients on opioid therapies MedicaSafeandapos s IMPACT will comprise prescrip ...

DESCRIPTION provided by applicant Primorigen Biosciences SBIR Proposal Abstract Primorigen Biosciences will develop a defined xenobiotic free synthetic cell culture matrix that fully supports maintenance and directed differentiation of human induced pluripotent stem cells hiPSCs down all three germ layers and dramatically reduces the costs of stem cell culture processes The current most co ...

DESCRIPTION provided by applicant Bringing new drugs to market is a lengthy and expensive endeavor To increase the number of affordable new drugs available to consumers at reasonable costs the efficiency of the drug development process must be greatly improved We aim to develop a novel tool that addresses this challenge by rapid identification of drug targets and drug candidates for any give ...

DESCRIPTION provided by applicant Novel transition metal complex cluster based probes for correlative light and electron microscopy CLEM and universally adoptable robust protocols for labeling whole tissue mounts will be developed The new probes and protocols will enable simultaneous localization of two or more antigens labeled using a single step labeling procedure Following fluorescence ...

DESCRIPTION provided by applicant This Small Business Innovation Research SBIR Phase I project will yield the first prototype of SpliceCore a cloud based resource for the discovery analysis and interpretation of Alternative Splicing AS from RNA seq data of all known diseases are triggered by defects in AS an mRNA maturation process that conveys functional diversity to genes Defect ...

DESCRIPTION provided by applicant Simplex Scientific LLC Simplex is proposing to develop a medical device that can accurately measure hypovolemia due to hemorrhage from trauma which can lead to shock and ultimately death and which will be suitable for deployment at civilian and military trauma sites and during transport where motion induced artifacts interfere with conventional technologies ...

DESCRIPTION provided by applicant The goal of this SBIR Phase I application from Sproutel is to develop a curriculum for providing expert educational content on diabetes self management to be delivered via principles of game based learning in an appealing teddy bear robotic character designed for young children diagnosed with type diabetes mellitus Type diabetes T D affects approximately ...

DESCRIPTION provided by applicant Recent advances in the development of therapeutic biomolecules derived from living organisms or biologics have lead to their widespread applications in the treatment of disease From monoclonal antibodies to recombinant proteins hundreds of biologics are now in the market pipeline As the use of such protein based treatments gains traction the requirements ...

DESCRIPTION provided by applicant We have discovered a novel method to eliminate specimen charging during scanning electron microscopic examination of tissue specimens using a metallographic staining technique that imparts bulk conductivity to embedded tissue This allows increased beam exposure and dwell time and when used in conjunction with backscatter electron detection and gold nanoparti ...

DESCRIPTION provided by applicant Autism Spectrum Disorder ASD is a significant medical problem ASD affects approximately of the population and extracts enormous emotional and financial costs from the afflicted and their families Despite years of research we understand very little about the molecular triggers of ASD and preventative therapeutics remain elusive Recently maternal immune ...