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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. A Nanofluidic Nanoplasmonic Platform for Multiplexing Detection of Cancer Biomark

    SBC: CFD Research Corporation            Topic: NCI

    DESCRIPTION (provided by applicant): This project aims to develop a novel nanofluidic-nanoplasmonic platform to realize multiplexed monitoring of biological binding processes, specifically for detection of cancer biomarkers in bio-fluids. In contrast to current large-sized, cumbersome surface plasmon resonance (SPR) sensing technology, the proposed device is comprised of a multilayer nanostructure ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Optimizing the Action Potential of Stem Cell-derived Human Cardiomyocytes for Car

    SBC: CHANTEST, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Stem Cell-derived Human Cardiomyocytes (SC-hCMs) offer great potential for improving the accuracy of pre-clinical cardiac safety screening. We have recently characterized a population of SC-hCMs that will be made commercially available in 2010 by our collaborator GE Healthcare, and have demonstrated that these cells show sensitive pharmacology that accurately p ...

    SBIR Phase I 2010 Department of Health and Human Services
  3. Positive Airway Pressure Gas Modulator- A Novel Method to Treat Central Sleep Ap

    SBC: CLEVELAND MEDICAL DEVICES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Sleep apnea is a major public health problem but traditional treatments have focused mostly on resolving obstructive sleep apnea (OSA) as demonstrated by the plethora of obstruction-motivated therapies like positive airway pressure, oral appliances, and others. However, more troubling forms of sleep apnea exist like those that are mediated by chemoreflex instab ...

    SBIR Phase II 2010 Department of Health and Human Services
  4. Discovery of Inhibitors of PTH-Wnt Signaling Synergy in Bone Cells

    SBC: DISCOVERYBIOMED, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): Project Summary Description Title: Discovery of Inhibitors of PTH-Wnt Signaling Synergy in Bone Cells. Osteoporosis is a growing problem in the aged and an unfortunately large disease market and burden to the healthcare industry. This debilitating disease costs 18 billion in healthcare costs annually in the US and affects 10 million people in the US and an est ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. Fluorescence Anisotropy-based Macromolecule Crystallization Screening

    SBC: IXPRESSGENES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Current practice is to set up trial crystallization screens and periodically review the results to see if a crystal or promising crystal-like precipitate has appeared a process that often takes weeks or months. Most outcomes are precipitated protein or clear drops, and the conditions that led to those results are removed from further consideration. We are deve ...

    SBIR Phase II 2010 Department of Health and Human Services
  6. Throughmask ElectroEtching for Cost-Effective Nitinol Stent Fabrication

    SBC: Faraday Technology, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Description Faraday Technology, Inc. proposes to develop the Faradayic ElectroEtching Process, based on pulsed electrolytic through-mask etching of nitinol stents, for rapid stent fabrication while maintaining pattern fidelity in a neutral, aqueous, non-toxic electrolyte. This process will enable stent manufacturing while minimizing process control difficultie ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. Ambulatory System for Hydrocephalus Shunt Monitoring

    SBC: H-CUBED            Topic: NINDS

    DESCRIPTION (provided by applicant): Each year, there are over 10,000 newborns diagnosed with hydrocephalus in the United States. Hydrocephalus, an excessive accumulation of cerebrospinal fluid (CSF) within the head, is a lifelong disease with no known cure. Fortunately, hydrocephalus can be managed with CSF shunts which redirect excessive CSF elsewhere in the body. Unfortunately, 30-40% o ...

    SBIR Phase II 2010 Department of Health and Human Services
  8. MRI Image Guided Radiation Therapy (IGRT) system with low cost, highly stable mag

    SBC: HYPER TECH RESEARCH, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Progress toward full development of ViewRay's Renaissance System 1000 MRI image guided radiation therapy (IGRT) system is being threatened by the growing shortage of helium worldwide. This pioneering technology is aimed at treating cancerous tumors in the abdomen where bodily functions cause significant organ displacements making precise dose delivery difficul ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. MULTIFUNCTIONAL SIRNA NANOPARTICLES FOR AML THERAPY

    SBC: NANOMATERIAL INNOVATION LTD            Topic: NCI

    This project will investigate transferrin (Tf) conjugated fluorescent nanoparticles loaded with an siRNA, LOR-1284, as a theranostic agent for acute myelogenous leukemia (AML). LOR-1284, a siRNA targeting the R2 subunit of ribonucleotide reductase (RNR), is a promising agent for overcoming RNR-mediated drug resistance in AML. The nanoparticles are designed to facilitate LOR-1284 delivery to AML ce ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. NeuroBehavioral Tool for Assessment of Sleep Structure in Psychiatric Disorders

    SBC: Neurowave Systems Inc.            Topic: NIMH

    DESCRIPTION (provided by applicant): The overall goal of this project is to develop a novel neuro-behavioral research/clinical tool (SleepMedic ) for quantitative analysis of brainwave (electroencephalogram, EEG) during overnight sleep (to monitor sleep architecture and quality), and during waking hours ( to quantify daytime sleepiness), in patients with psychiatric disorders. SleepMedic will con ...

    SBIR Phase I 2010 Department of Health and Human Services

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