Award Data

Iron deficiency is one of the most common nutritional deficiencies in the United States. Left untreated, iron stores continue to deplete, resulting in iron deficiency anemia. Women undergoing basic military training are particularly susceptible to reduced iron stores. To date, there are no comprehensive point-of-care instruments for accurate determination of iron status. We propose to develop a no ...

DoD requires a single multiplexed salivary diagnostic bioassay to indicate early multiorgan injury to determine systemic toxicity. This assay should detect clinically validated biomarkers quantitatively in saliva to indicate organ injury due to chemical/xenobiotic exposure. Innosense LLC (ISL) will innovate on its proprietary polymer nanowire platform to fabricate Nano-Mos, which will detect saliv ...

Rapid diagnosis in combat areas is a growing military need specifically as troops are exposed to chemical threats with significant adverse health effects (http://www.army.mil/e2/c/downloads/351235.pdf).Testing of biomarkers in saliva has recently shown great promise in diagnostics, prognostics, and treatment efficacy follow-up. In addition to its convenience for field sampling and rapid testing, s ...

Combat soldiers are exposed to vast numbers of dangerous chemicals with potentially adverse health outcomes.This SBIR proposal aims to develop a new class of saliva based diagnostic assays that will measure the bodys response to toxic chemical exposure via a panel of clinically used biomarkers that are indicative of organ injury.The tests will leverage the proven functionality of lateral flow diag ...

The applicant developed the modular Sterile Saline Solution System (S4), for remote site production of Sterile Physiologic Saline. It used Available Surface Water of poorer quality for particulates, chemical contaminants, microbes and biologicals than the EPA Grade Drinking Water Standards (EGDWS) specifies and dry reagent formulation. This system is the subject of an FDA assigned Investigational ...

Currently, deployed medics are required to transport, maintain and be resupplied with liquid-based medications and materials that are heavy, expensive to transport, perishable and may require refrigeration.Many medications and materials are or will be available in dehydrated formularies that require sterile water for injection (SWFI) to rehydrate for immediate use, such as freeze-dried platelets.I ...

A recent study of battlefield casualties found that over 90% of potentially survivable mortality cases were associated with hemorrhage. It is critical to maintain fluids and prevent hemorrhagic shock as soon as possible after the injury. However, medics must plan for and carry these bulky solutions to the point of injury, and additional casualties could exhaust limited available supplies. Mainstre ...

To address the DHP need for a deployable, controlled hypothermia device, Physical Optics Corporation (POC) will further improvise on our Fast and Smart Cooling Equipment for Enhanced Neuroprotection (FASCOOL) based on research results of a previously funded DARPA SBIR. The FASCOOL program will leverage findings from that program and augment the device by adding a new feedback/control mechanism to ...

Our proposal specifically addresses the stated requirements of the solicitation: we will develop and deploy tools, methods, and models for the research and design of a unique system referred to as BrainCool. The EDAptive BrainCool solution builds on previous ECI knowledge and technologyitself innovativeto solve the problem of Brain Temperature Management. Innovations required include measuring bra ...

Traumatic brain injury (TBI) impacts over two million Americans annually, and is the signature injury of the Iraq and Afghanistan conflicts. Therapeutic hypothermia is a promising neuroprotective technique for treating TBI, but reduced body temperature is a threat to soldiers in military operations with multiple injuries. Mainstream has proposed a novel vapor compression cooling system that overco ...