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SBC: PHAGEPRO, INC. Topic: NIAID
PROJECT SUMMARY Cholera is an acute and severe disease caused by the bacterium Vibrio cholerae that is spread primarily through contaminated water sources due to a lack of adequate sanitation infrastructure. The World Health Organization estimates that there are at least 3 million cases globally per year, 40 percent of which are spread through household transmission. Current prevention methods req ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: APTIMA INC Topic: DHA18B001
Current cervical spine assessment methodologies are focused on subjective measures (i.e. pain reports) and range-of-motion (ROM) measures that only measure maximum head excursion and reach, but not dynamic motion. Due to report bias and existing incentiveSTTR Phase I 2019 Department of DefenseDefense Health Agency
SBC: SWITCHBOX INC Topic: DHA18B001
Most standard-of-care tools and techniques for evaluating neck disorders are subjective, unreliable, and do not provide actionable information for providers, payers, and organizations to deliver efficient and effective care. This lack of objective neck heSTTR Phase I 2019 Department of DefenseDefense Health Agency
Development of a predictive moderate throughput assay to screen novel Designer Proline-rich antimicrobial peptide Chaperone protein inhibitors (DPCs) against multi-drug resistant pathogenSBC: Arrevus, Inc. Topic: NIAID
Multi drug resistantMDRbacterial infections represent a significant threat to public healthIt is estimated that the impact of antibiotic resistance will continue to grow resulting in a global economic burden of $trillion and causingmillion deaths annuallyMany of the therapeutics currently under development represent traditional antibiotic approaches or next generation antibiotics that will likely ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: ASPIREBIO CORP Topic: 101
PROJECT SUMMARY Opioid drugs are powerful analgesicsbut their side effect profile strongly limits their useIndeedtheir addictive properties have led to an epidemic of abuse in the US that accounts forof the global utilization of prescription opioid analgesics in the USwith a market of over $billion per yearPrevious studies have shown that the endocannabinoid neurotransmitteranandamidecontrols noci ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
A momentum-enabled treadling methodology to improve gait and enhance mobility in patients with peripheral arterial diseaseSBC: TREADWELL CORPORATION Topic: NIA
Project SummaryA significant cause of mobility impairment in the elderly is peripheral arterial diseasePADPAD results in significant functional declinereduced walking speed and distanceand lower physical activity levelsresulting in a loss of independence and impaired quality of lifeThe most effective therapy for PAD is rigorous exercisee gwalkingHowevermost PAD patients will not participate in sup ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: AegisCN LLC Topic: 106
ABSTRACT Intracerebral hemorrhageICHis a devastating form of cerebrovascular disease with no FDAapproved treatmentsIt is generally accepted that ICH induced neuroinflammatory responses mediate development of cerebral edemaintracranial hypertensionand secondary neuronal injuryOne promising strategy for ICH neuroinflammatory modulation is through the downstream effects of apolipoprotein EapoEPreviou ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: BERTEC CORP Topic: NIA
Falls are a significant source of early morbidity and mortality in the aging populationyet the neurologicalsensoryand motor changes that lead to increased fall risk often escape early identification and interventionVital signs are commonly used in clinical settings to assess the cardiovascular systemblood pressureheart rateimmune systembody temperatureand the respiratory systemrespiratory rateto e ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Astrocyte activation by small-molecule ADORA3 agonists: a novel therapy for Alzheimer's diseaseSBC: ASTROCYTE PHARMACEUTICALS INC. Topic: NIA
PROJECT SUMMARY Alzheimerandapos s diseaseADis an area of significant unmet need that creates a national burden of$billion annuallyAD is the leading cause of dementiaaffectingof Americans over the age ofDemographic shifts and the age related nature of AD will soon place this disease as the costliest health care expenditure in the U Swith a projected impact of $trillion per year byCurrent therapies ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: BIOSENSICS LLC Topic: NIA
AbstractCognitive frailtythe combined presence of physical frailty and cognitive impairmentis a strong and independent predictor of cognitive declineThe International Association of Gerontology and Geriatrics and the International Academy on Nutrition and Aging have recommended the use of cognitive frailty assessment to track the progression of mild cognitive impairmentMCItowards dementiaAlzheimer ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health