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SBC: INVENTORS WORKSHOPS INC Topic: NIA
AbstractPersons living with dementiaPWDoften require assistance with routine activities and daily tasksWorkloads placed on caregivers often results in high levels of physical and emotional stressand depressionand higher overall morbidity and mortality ratesFocus group of caregivers for individuals with mild to moderate dementiaidentified dressing the PWD as the most pressing and stressful daily co ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Novel and potent SHIP1 inhibitors for improving hematologic recovery following myelosuppressive therapiesSBC: Alterna Therapeutics, Inc. Topic: NHLBI
ABSTRACT Despite recent advances in targeting cancer cellschemotherapy remains a mainstay of oncologyextending survival and providing cures for many types of cancerHoweverchemotherapy that ablates or suppresses bone marrow cells can be debilitating even when combined with autologous hematopoietic stem cell transplantationHSCTThe treatment causes severe side effects such as anemianeutropenia and th ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: TRICORDER ARRAY TECHNOLOGIES LLC Topic: 100
PROJECT SUMMARY The for profit small business concernTricorder Array Technologies LLCwill developin partnership with the University of Alabama at BirminghamSIDECAReSensing and Integrating Data for Environmental Conditions in Animal ResearchThis device will automate collection of relevant data that will enhance consistency in animal models used to study human health treatment researchOur innovative ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: INSOMA BIO, INC. Topic: 102
Abstract The objective of this proposal is to validate a new regenerative tissue matrix which studies to date indicate may be possible of redefining the limits of autologous fat graftingThis objective is motivated by the currently limited surgical options available to themillion patients undergoing reconstructive plastic surgery each year to treat body disfigurement and dysfunctionA core component ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: Panacise Bio, Inc. Topic: 102
Abstract This project seeks to develop the next generation pro CARs that are inactive in normal tissues but selectively activated in the tumor microenvironmentTMEThe project is based on our previous development of a novel class of chimeric antigen receptors on the basis of single domain antibody mimics that recognize ErbB family membersSDAErbBon the surface of cancer cellsWe propose two specific a ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: KITWARE INC Topic: NHLBI
ABSTRACTPrematurity is the largest single cause of death in children under five in the world and lower respiratory tract infectionsLRTIare the top cause of hospitalization and mortality in premature infantsClinical tools to predict and prevent severe LRTI in premature pediatric patients are critically needed to allow early interventions to decrease the high morbidity and mortality in this patient ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Fawkes Biotechnology, LLC Topic: 100
Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Universal Adherence LLC Topic: N
Project Summary Abstract Universal Adherence is an emerging medical device company dedicated to improving adherence to ocular medications through innovative technical solutionsOur proposed Devers Drop DeviceDwill accurately track when a patient removes an eye drop bottle capcommunicate usage data wirelessly to a database that researchers can accessand send alerts to patients when a medication is d ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: BRILLIANT BIOSCIENCES INC. Topic: NIA
One in ten of the persons ageare affected by Alzheimer s diseaseADcausing enormous social and economic burden to the United StatesTo date only five medications have been approved by the FDA for the treatment of the symptoms of ADbut none of them slows or stops the disease progressionWith the recent repeated failures of AD drugs on thesecretase inhibitorsthe need for an effective AD drug became eve ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: BIOSENSICS LLC Topic: NIA
ABSTRACT The recent shift in Alzheimer s diseaseADclinical research from clinical diagnosis toward the goal of developing neuroprotective therapies has highlighted the need for a robust and rapidly administered cognitive assessment tool capable of identifying individuals in the earliest stages of cognitive decline and measuring subtle changes in cognitive motor performance over timeIn this context ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health