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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Commercialization of a Diagnostic Test for Alzheimer's Disease

    SBC: SCOUT DIAGNOSTICS            Topic: NIA

    DESCRIPTION (provided by applicant): The major barriers to preventing or treating Alzheimer's disease (AD) are its unknown pathogenesis/etiology and the lack of an objective, sensitive and specific biomarker of the disease, particularly at the early stages when therapeutic interventions would likely have the greatest efficacy. The basic hypothesis of this project is that levels of a unique high mo ...

    STTR Phase II 2010 Department of Health and Human Services
  2. Novel estrogen receptor ligands from plant genomics

    SBC: NAPROGENIX, INC.            Topic: NCCAM

    DESCRIPTION (provided by applicant): Human nuclear receptor (HNR) ligands have potential value as pharmacotherapies or chemopreventive agents for many hormone-responsive cancers. The primary aim of this STTR is to transfer an academic plant genomics technology into drug discovery, targeting HNR ligands. Estrogen receptor (ER) ligands in plants will be used for proof of application, because these ...

    STTR Phase II 2010 Department of Health and Human Services
  3. A device containing an immobilized chelator to remove aluminum from total parente

    SBC: ALKYMOS, INC            Topic: NICHD

    DESCRIPTION (provided by applicant): A high percentage of the ~ 500,000 children born prematurely each year in the US require intravenous feeding after birth because they do not tolerate oral feeding. This is accomplished with a total parenteral nutrition (TPN) solution, which is prepared from component solutions: small and large volume parenterals (SVPs and LVPs). Aluminum (Al) is a common contam ...

    STTR Phase II 2010 Department of Health and Human Services
  4. Acute-infarct selective cardiac MRI contrast agent

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

    STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  5. Disposable Instrument for Broader Patient Access to Vision Restoration Therapy

    SBC: Ocular Transplantation LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Retinal diseases such as age-related macular degeneration (AMD), retinal dystrophies, and retinitis pigmentosa (RP) affect millions of Americans. As the population ages, this number will grow significantly. Many people will lose their sight due to degeneration of photoreceptors and/or retinal pigment epithelium (RPE). The majority of clinical studies performed ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Novel SCID rat models for human cell transplantation studies

    SBC: TRANSPOSAGEN BIOPHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The laboratory rat is used extensively by the pharmaceutical industry for preclinical animal efficacy and toxicology studies. In addition, the rat has been a valuable animal model for physiology, behavior, and pharmacology research programs, due to ease of experimental manipulation. Their larger size facilitates procedures otherwise difficult in mice, including ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms

    SBC: DISCOVERYBIOMED, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Title: Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms Project Summary Statement The Problems: Complementary and alternative medicine (CAM) is an understudied scientific discipline. It is unappreciated that many biologically active and therapeutically beneficial compounds are derived from botanicals. Moreover, the scientific me ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Fully Biodegradable Polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-b

    SBC: VINDICO NANOBIOTECHNOLOGY, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Vindico NanoBioTechnology Inc. (Vindico) is developing a hemoglobin-based cellular oxygen therapeutic (blood substitute), NanoHeme, based on its proprietary nanoparticle-based delivery platform known as polymersome. Polymersomes are synthetic polymer vesicles that are formed in nanometric dimensions which can efficiently encapsulate oxygen-carrying proteins ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. High-Throughput Ex Vivo Tumor Cell Motility Assay

    SBC: Nanofiber Solutions, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Gliomas are the most aggressive and least successfully treated brain tumors because of their distinctive ability to infiltrate surrounding brain tissue. Even if the bulk of the tumor is removed, migratory cells left behind are not detected by the immune system and resist current cytotoxic therapies. Tumor recurrence then typically involves a rapid and deadly ou ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Development Lateral Flow Assay

    SBC: KENTUCKY PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this project is to develop a lateral flow assay for detecting complement levels and complement activation status in a patient. This assay will give results in seconds versus either hours or days that normal complement lab assays have. It also will give more accurate results than conventional assays. The complement system is a group of more than 30 s ...

    SBIR Phase I 2010 Department of Health and Human Services

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