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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Targeting the sphingolipid pathway for the R&D of new antifungals
SBC: MICRORID TECHNOLOGIES INC Topic: NIAIDABSTRACT The goal of this project is to discover and develop a new therapeutic smore potent than current antifungals for the treatment of invasive fungal infectionsAmong invasive fungal infectionscryptococcosiscandidiasisand aspergillosis are the most life threateningThe incidence of these infections has risen more thanfold over the lastyearswith a mortality rate ofyearWe recently discovered a fun ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Novel Home-Based and Low-Cost ECG Device for periodic evaluation of the presence of atrial fibrillation
SBC: Global Instrumentation, LLC Topic: 600Abstract Atrial fibrillationAFprevalence is estimated toof the general population in the United StatesA shockingtoaccording to studiesof patients with AF are unaware of their diagnosissilent AFMost AF patients will suffer from congestive heart failure or and develop thromboembolic events leading to a dramatic reduction of patientsquality of lifeand a significant consumption of health care resource ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Targeting the host response to limit infection by intracellular bacterial pathogens
SBC: Blue Ridge Biosciences, LLC Topic: NIAIDAntibiotic development has traditionally focused on drugs that target the pathogen but resistance inevitably developsAn attractive alternative is to develop drugs that target the host response and in particular for facultative obligate intracellular bacterial pathogenswhich rely on the host for disease progressionIntracellular bacterial pathogens manipulate the host cytoskeletal system to their ad ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Nanofiber Expanded CD34+ Stem Cells for Osteoporosis Therapy
SBC: HNB Therapeutics LLC Topic: NIASummary Glucocorticoid induced osteoporosis is the most common cause of secondary osteoporosisand the primary cause before ageIt affects overof the general populationwhereinare womenIn postmenopausal women and men agedand overtreatment would be recommended in at least half based on theAmerican College of Rheumatology guidelinesAdult stem cells are a promising class of regenerative cellssome lineag ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Functionalized, Therapeutic-Loaded Liposomes for the Acute Treatment of TBI
SBC: LUNA INNOVATIONS INCORPORATED Topic: DHA18A001Traumatic brain injury is a common problem in both the military and civilian communities, but current treatment protocols are focused on managing symptoms and fail to prevent significant long-term repercussions. In the proposed program, Luna will demonstrate the feasibility of a liposome-based therapeutic delivery system capable of delivering hydrophilic and hydrophobic therapeutics to the traumat ...
STTR Phase I 2018 Department of DefenseDefense Health Agency -
Enzymatic attachment of proteins to fluorescent nanodiamond surfaces.
SBC: COLUMBUS NANOWORKS, INC. Topic: 400Fluorescent nanodiamonds are biocompatibleinfinitely photostableand fluoresce in a variety of wavelengthsincluding the near infraredNIRregionThese characteristics suggest transformative applications in areas ranging from pure biological research to biomedical imagingwhere protein conjugated nanodiamonds could be targeted to specific tissues in living patients or even structures within individual c ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Imaging Biomarkers of Severe Respiratory Infections in Premature Infants
SBC: KITWARE INC Topic: NHLBIABSTRACTPrematurity is the largest single cause of death in children under five in the world and lower respiratory tract infectionsLRTIare the top cause of hospitalization and mortality in premature infantsClinical tools to predict and prevent severe LRTI in premature pediatric patients are critically needed to allow early interventions to decrease the high morbidity and mortality in this patient ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Microfluidic CAR-T Cell Processing Device
SBC: GPB Scientific, Inc. Topic: 101ABSTRACT The goal of this Fast Track STTR project is to develop a Deterministic Lateral DisplacementDLDmicrofluidic device that can enrich white blood cellsWBCsfrom a typical leukapheresis unit inhrfor use in manufacturing cancer cellular immunotherapyChimeric antigen receptor T cellCAR Ttherapy has been recommended for FDA approval to treat relapsed or refractory pediatric and young adult patient ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Targeting glioblastoma stem-like cells with custom-designed viral vectors
SBC: Lacerta Therapeutics, Inc. Topic: 102Abstract GlioblastomaGBMis the most lethal form of adult brain cancers with a median survival of andltmonths despite aggressive standard chemoradiationGBM are formed by GBM stem like cellsGSCsa major contributor to tumor recurrence and a natural focus for therapeutic developmentThere are two main reasons responsible for treatment failurehigh intraand inter tumor cellular and molecular heterogeneit ...
STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health -
Fast Parameter Identification for Personalized Pharmacokinetics
SBC: AUTONOMOUS HEALTHCARE INC Topic: DHP17B003Drug dosingcan bemademore precise by using pharmacokineticand pharmacodynamicmodeling. Pharmacokinetics is thestudy of the concentration of drugs in tissueasafunction of timeand doseschedule,whereas pharmacodynamics is thestudy of therelationship between drugconcentration and drugeffect. By relating doseto resultant drugconcentration (pharmacokinetics)and concentration to effect (pharmacodynamics) ...
STTR Phase I 2018 Department of DefenseDefense Health Agency