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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. High Throughput Lethality Screen in Drosophila Against Tumor Metastasis

    SBC: MEDROS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Cancer continues to be a growing health issue. Overall five-year survival rates have changed only marginally over the past three decades and success rates in putting cancer drugs through the clinic have not improved. Th ese facts highlight an unmet need not only for new therapies but, more importantly, for novel approaches toward the discovery of safe anti-canc ...

    SBIR Phase I 2008 Department of Health and Human Services
  2. Development of Hermetic Sealing Glasses for Solid Oxide Fuel Cells

    SBC: MO-SCI Corp.            Topic: H801

    Sealing glasses, either rigid glass-ceramics or viscous, non-crystallizing compositions, will be developed and sealing processes will be optimized based on NASA's solid oxide fuel cell (SOFC) designs. SOFC design constraints, including material selection and operational conditions, will guide compositional development, and then these new compositions will be used for long-term (>500 hours) materia ...

    SBIR Phase I 2014 National Aeronautics and Space Administration
  3. Integration of Complex Geometry, 3D Woven Preforms via Innovative Stitching Technique

    SBC: T.E.A.M., INC.            Topic: H701

    Thick, 3D woven carbon/phenolic composites offer potential improvement over legacy thermal protection systems (TPS) for re-entry vehicle heat shield applications. However due to the scale and complexity of typical re-entry vehicle structures, it is likely that multiple 3D woven panels would need to laid up to create the overall heat shield, creating a potential weak spots at the panel joints. ...

    SBIR Phase I 2014 National Aeronautics and Space Administration
  4. Advancing High Energy Lithium-Sulfur Batteries

    SBC: Yardney Technical Products, Inc.            Topic: Z102

    Lithium-Ion batteries have been a main source of energy for many aerospace applications over the past decade. Future space missions are facing a number of challenging requirements, including significant increase in specific energy, approaching 500 Wh/kg, and energy density of 700 Wh/l at cell level. Compared to state-of-the-art technology today, a reduction in mass and volume are necessary, along ...

    SBIR Phase I 2014 National Aeronautics and Space Administration
  5. Quantitative I-123 Cardiac SPECT using a Novel Spectral Fitting Method for High E

    SBC: CARDIOVASCULAR IMAGING TECHNOLOGIES            Topic: N/A

    DESCRIPTION (provided by applicant): Current emphasis on metabolic approaches and models for diagnosing heart disease have renewed development of 123I SPECT imaging agents applied in stand-alone protocols and as a complimentary role to existing stress/rest perfusion protocols. However, a majority of the current nuclear cardiology SPECT equipment base and associated infrastructure utilize low ener ...

    SBIR Phase I 2008 Department of Health and Human Services
  6. Assay for Detection of Loxosceles Envenomation

    SBC: STOECKER MD, WILLIAM V            Topic: N/A

    DESCRIPTION (provided by applicant): Envenomations by the brown recluse spider, Loxosceles reclusa, are a significant source of morbidity in endemic regions of the United States, and misdiagnoses are common. A survey of physicians in the endemic area has shown the economic viability of an accurate diagnostic test for these spider bites. Development and testing of an optimized Loxosceles venom as ...

    SBIR Phase I 2008 Department of Health and Human Services
  7. Novel and Effective Antifungal Compounds Derived from Molecular Field Analysis

    SBC: Divergence, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Invasive fungal infections are an increasingly common and serious cause of illness and death in the U.S. and worldwide. Infection by Candida albicans has increased tenfold to become more frequent than diseases caused by E. coli and Pseudomonas, and it has become one of the most common fatal infections in the United States. Clinical management of invasive funga ...

    SBIR Phase I 2008 Department of Health and Human Services
  8. IN VIVO COMPATIBLE AND READILY INJECTABLE GOLD NANO CONSTRUCTS FOR TUMOR THERAPY

    SBC: NANOPARTICLE BIOCHEM, INC.            Topic: N/A

    The objective of this proposal is to develop nanoparticulate therapeutic products from the readily injectable Gold-198 (Au-198) nanoconstructs invented at the University of Missouri and licensed to Nanoparticle Biochem, Inc. The Phase I effort embodies three aims: (1) Optimization of synthetic protocols, large scale production, and quality control capabilities of Au-198 nanoparticles (NP) and thei ...

    SBIR Phase I 2008 Department of Health and Human Services
  9. DGPS-Based Trilateration Positioning Receiver

    SBC: Swaszek Peter            Topic: 07FH1

    Positioning and navigation have become a mainstay of everyday life in the U.S.; applications of interest include navigation of vehicles of all kinds, infrastructure mapping, and safety of life systems. Many of these recent applications have become possible through the GPS. With the recognized vulnerabilities of GPS, it is evident that equivalent backup systems must be developed. One possible so ...

    SBIR Phase I 2008 Department of Transportation
  10. Novel Macrofilaricidal Compounds: Target Identification and Chemical Optimizatio

    SBC: Divergence, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Parasitic infect over 140 million people, with up to one billion at risk in 80 countries. Lymphatic filariasis creates an enormous health and economic burden within affected areas and is the second leading cause of long -term disability. In 2000, international groups including the World Health Organization (WHO) launched an initiative to eliminate lymphatic fil ...

    SBIR Phase I 2008 Department of Health and Human Services

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