Award Data

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DESCRIPTION (provided by applicant): The ability to define the location of airway obstructions in Obstructive Sleep Apnea (OSA) patients is critical for surgical and oral appliance treatments because these therapies target the manipulation or removal of specific collapsible oropharyngeal regions. Yet, to this date, there are no adequate tools that can accurately and conveniently locate the collaps ...

DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess ParkinStep , a compact, portable, wireless movement disorder monitor technology to quantify gait and balance performance in Parkinson's disease (PD). A standardized platform for repeatable, automated testing to assess gait and balance in response to deep brain stimulation (DBS) settings should optimize p ...

DESCRIPTION (provided by applicant): The objective is to design, implement, and clinically assess a portable, user worn, bradykinesia feature extraction system, BradyXplore , for easy integration with CleveMed's existing ParkinSense technology platform. Idiopathic Parkinson's disease (PD) and other parkinsonian disorders affect millions of people. Three major symptoms responsible for functional d ...

DESCRIPTION (provided by applicant): The peripheral chemoreceptors (carotid primarily, and the aortic bodies) detect changes in arterial blood oxygen and carbon dioxide, and initiate reflexes that are important for maintaining homeostasis during hypoxemia. The response to changing carbon dioxide (CO2) levels produces major changes in respiratory drive, of special importance to the control of venti ...

DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess a system for automated telehealth diagnostics for remote Parkinson's disease (PD) monitoring. Currently in the United States, there are approximately 1 million patients living with PD and 50,000 new cases reported each year. However, there is limited access to movement disorder specialist centers for a si ...

DESCRIPTION (provided by applicant): The objective is to design, implement, and clinically assess ETSense , an adaptive, compact, portable essential tremor (ET) monitor for optimizing therapeutic interventions. ET affects approximately 4% of the population over age 40 in the United States and is characterized primarily by postural and kinetic (action) tremors of the limbs, which are rated by vario ...

Clifton Labs, Inc. proposes to develop a web-based hardvare/softvare co-design, distributed library, and distributed co-simulation environment, called DISCOE. The environment will use the SUAVE extensions to VHDL for design capture (specification) of hardvare/softvare systems. The SUAVE extensions seamlessly integrate with the current VHDL language standard and are necessary for effective softwa ...

DESCRIPTION (provided by applicant): Our objective is to develop new drug treatments for the side effects of levodopa (L-DOPA) that occur in people with Parkinson's Disease. L-DOPA is the gold standard of treatment for Parkinson's, but unfortunately, the majority of people who take L-DOPA eventually develop debilitating side effects, abnormal involuntary movements called dyskinesias, which may aff ...

A Phase I analytical program is proposed for an indirect means of reducing the temperature of gas turbine engine hot-section cooling air. The Indirect Cooling System (ICS) uses engine fuel as the heat sink in a manner similar to work already accomplished by the USAF IHPTET program. ICS provides additional advantages in terms of fire safety, reduction in exposure time to fuel deposit formation, t ...