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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Bullet Proof vascular graft to prevent dialysis access cannulation injury

    SBC: Innavasc Medical, Inc.            Topic: 400

    Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

    STTR Phase I 2016 Department of Health and Human Services
  2. A novel protein engineering tool for rapid manufacturing of designer nucleosomes

    SBC: EPICYPHER, INC.            Topic: 103

    PROJECT SUMMARY Nucleosomes are the basic building blocks of chromatin and composed of bp DNA wrapped around a core histone octamer Chromatin function is controlled by the dynamic addition removal of histone post translational modifications PTMs Significantly alterations in specific PTMs are associated with changes in gene expression driving the emergence progression of many cancer ...

    STTR Phase I 2016 Department of Health and Human Services
  3. Nasal Leptin- Polymer Conjugate for Treatment of Obesity

    SBC: NEURO10-9 PHARMA INC            Topic: 300

    DESCRIPTION provided by applicant Despite their increased risk of developing serious diseases including coronary heart disease Type diabetes hypertension certain types of cancers and stroke the public health crisis of individuals who are overweight or obese continues unabated Safety issues have hampered development of drugs designed to control weight and the four drugs currently on the ...

    STTR Phase I 2016 Department of Health and Human Services
  4. Directed Chemotherapy Delivery for Leptomeningeal Metastases

    SBC: Minnetronix Medical, Inc.            Topic: 102

    DESCRIPTION provided by applicant Directed Chemotherapy Delivery for Leptomeningeal Metastases PI Lad Shivanand and McCabe Aaron Project Summary Leptomeningeal Metastases LM is a condition in which cells from a primary solid or hematological tumor metastasize invade the subarachnoid space and spread throughout the cerebrospinal fluid CSF resulting in seeding of the leptomeninges along ...

    STTR Phase I 2016 Department of Health and Human Services
  5. Drug Activation of HSF1 for Prevention of Noise-Induced Hearing Loss

    SBC: CHAPERONE THERAPEUTICS, INC.            Topic: NIDCD

    PROJECT SUMMARY The studies proposed here address a significant health issue the high incidence of acquired deafness from noise overstimulation that can result from recreational and workplace related activities and from service in the military Through a robust academic pharma partnership between investigators at the Kresge Hearing Research Institute with long standing interests and expertise in ...

    STTR Phase I 2016 Department of Health and Human Services
  6. The Impact Integrated Data System for Quality and Outcomes Tracking of Prevention Programs

    SBC: 3-C Institute for Social Development, Inc.            Topic: 104

    There has been substantial progress in developing evidence based prevention programs EBPPs for preventing risky behaviors and promoting positive outcomes for youth Unfortunately their adoption quality implementation long term sustainability and scalability in real world service settings continues to lag far behind resulting in an inability to achieve the intended broad scale public impact ...

    SBIR Phase I 2016 Department of Health and Human Services
  7. Using Meta-level Smartphone Data to Promote Early Intervention inSchizophrenia

    SBC: Health Outcomes Inc            Topic: 102

    Project Summary andquot Using Meta level Smartphone Data to Promote Early Intervention in Schizophrenia Schizophrenia is one of the most debilitating disorders in the world today It affects over million adult Americans each year NIMH director Dr Thomas Insel has declared The best chance for preventing serious functional disability among people with schizophrenia may be to intervene at th ...

    SBIR Phase I 2016 Department of Health and Human Services
  8. Nomethiazoles harnessing GABA and NO mimetic activity for Alzheimer s therapy

    SBC: sGC Pharma Inc.            Topic: NIA

    DESCRIPTION provided by applicant Alzheimerandapos s disease AD occurs in one out of eight Americans of age and affects of the elderly over Current FDA approved drugs provide short term symptomatic relief of AD There is a pressing need to discover new disease modifying medications AD is multifactorial in origin and progression A drug attenuating several underlying factors is a p ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. "Speed Bumps": A non-invasive quantitative test for early detection of neuropathy in the feet

    SBC: Neuro Devices, Inc.            Topic: 101

    ABSTRACT This STTR Phase I resubmission describes a small deceptively simple portable device called Speed Bumps that rapidly quantifies the sensation of flutter on the feet toes or fingers in micrometer m units Flutter frequency is to Hz which is below the approximate lower vibration range of to Hz This high sensitivity device is designed to differentiate the small variati ...

    STTR Phase I 2016 Department of Health and Human Services
  10. Multi-Channel Transmit- Multi-Channel Receive Coil Array for Human fMRI

    SBC: LIFE SERVICES L.L.C.            Topic: 101

    DESCRIPTION provided by applicant For this Phase I STTR proposal the investigators plan to develop the radiofrequency RF coil technology required for high resolution fMRI at T In the absence of a body transmit coil all T head coils must also incorporate a transmitter in addition to the receiver Here we propose a transmit array with up to individual channels combined with a receive a ...

    STTR Phase I 2016 Department of Health and Human Services

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