Award Data

ABSTRACTAn Innovative Unbound Bilirubin Assay to Identify Bilirubin Induced Neurological DysfunctionBINDRisk asPart of a Comprehensive and Novel Point of Care Newborn Screening PanelFast Track SBIRNeonatal hyperbilirubinemiaor elevated bilirubinoccurs in overof newborns and results in jaundiceWhen treated promptlyhyperbilirubinemia is usually benign but if left untreated elevated bilirubin levels ...

PROJECT SUMMARYThe complex organization of chromatinDNA with its associated nuclear proteinsis closely tied to the regulation of gene expressionand evidence points to a central role for chromatin deregulation in tumor developmentA common analysis of chromatin regulatory protein localization is the chromatin immunoprecipitationChIPassaywhich involves crosslinking of proteins to DNAfollowed by chrom ...

Project Summary Therapies based on Chimeric Antigen ReceptorsCARor T Cell ReceptorsTCRhave shown incredible potential as personalized immunotherapies for cancer patients which involves enrichment and modification of immune cells to express targeting moieties against cancer cellsStudies have shown that deriving therapies from well defined sets of cell subpopulations have superior potency and sustai ...

This Fast Track SBIR grant proposal seeks to develop a new class of macrocylic peptide drugs for treatment of systemic candidiasisan increasingly frequent cause of serious and often fatal infections in hospitalized and immunosuppressed patientsMortality rates associated with these infections have risen sharply due to the emergence of multidrug resistantMDRstrains of Calbicans and other Candida spp ...

Project Summary Acute Kidney InjuryAKIcommonly occurs in critically ill patients in the ICUPatients with severe AKI often require continuous renal replacement therapyCRRTbecause it enables hemodynamic stability and better volume controlAnticoagulation therapy is frequently used to keep the CRRT circuitespecially the blood filterfrom clotting as many critically ill patients are prothromboticand or ...

Abstract The goal of the proposed research is to translate empirical evidence into a behavioral intervention targeting AthletesParentsand CoachesAPCto decrease the time between concussion injuryonset of symptomsand medical treatment among youth sport athletesNearlymillion sport related concussionsSRCare reported annually in the USand this number has been steadily increasingin part due to greater a ...

Project SummaryGenome editing technologies, such as CRISPR/Cas9 provide a rapid, and targeted means of both knocking out gene expression and knocking in gene modifications. Since our initial Phase I submission, the utility of CRISPR technology has expanded beyond the generation of cell lines, to forward genetic screening, in vivo manipulation of gene expression and even human therapeutics. Phase I ...

PROJECT SUMMARYNucleosomes are the fundamental repeating units of chromatincomprised of four core histone proteins that are subject to a variety of post translational modificationsPTMse glysine methylation and acetylationEpigenetic reader proteins coordinate the cellular response to these PTMs by influencing chromatin compaction and gene expression through domains that recognize specific PTMsA rap ...

Project SummaryGenome wide functional genetics has been recently made possible by pooled library based CRISPR Casgene editing technologyBy randomly knocking out thousands of geneslarge scale screens can be conducted for functional geneticsdrug sensitivity and other phenotypesCurrently howeverthis forward genetic approach is largely relegated to live dead screens in mammalian cellsImproving the sop ...

Alcohol consumption has widespread prevalence with global impact on societies, economies, and health. Overconsumption and misuse of alcohol has led to significant burdens, including nearly 88,000 fatalities in 2006 (CDC, 2013), contribution to more than 200 diseases and injury-related health conditions totaling 5.1% of the burden of disease and injury worldwide (Sacks, 2014), and costs greater tha ...