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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Complete genome de novo assembly software for the emerging long read sequencing era

    SBC: DNASTAR, INC.            Topic: 400

    Despite the tremendous success of short read next generation sequencingNGStechnologiestheir inherent inability to establish long range connectivity makes fundamental tasks such as genome closurehaplotype phasing and alternatively spliced transcript characterization all but impossibleNowtwo long read sequencing providersPacific BiosciencesPacBioand Oxford Nanopore TechnologiesONTare producing data ...

    SBIR Phase II 2017 Department of Health and Human Services
  2. Wearable Liquid Crystal Based Chemical Sensor Badge for the Identification of Toxic Industrial Chemicals

    SBC: Platypus Technologies, LLC            Topic: HSB0171006

    Toxic Industrial Chemicals (TICs) pose significant dangers to human health upon exposure. Unfortunately, emergency responders are unwittingly exposed to these TICs while responding and containing crisis situations, leading increased risk for disease. To protect emergency responders against dangerous exposure to chemicals, Platypus Technologies will develop a wearable chemical sensor badge that c ...

    SBIR Phase I 2017 Department of Homeland Security
  3. HTS Assays for Targeting the cGAS STING Pathway in Autoimmune Diseases and Cancer

    SBC: Bellbrook Labs, LLC            Topic: 300

    SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferon IFN response via activation of the STING stimulator of interferon genes receptor The sensor for cytoplasmic nucleic acids was recently discovered to be a cyclic GMP AMP synthase which produces a unique cyclic dinucleotide second messenger cGAMP that serves as an agonist fo ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. High Fidelity Linear MicroVector to Clone Complex Problematic and Large DNAs

    SBC: Varigen Biosciences Corp            Topic: 200

    The goal of this research is to dramatically improve the ability to clone and analyze large and unstable DNA fragments We propose to develop a novel linear cloning vector to maximize stability of cloned DNA in the bacterial host The vector will use the replication proteins of the phage Phi to achieve the highest accuracy of replication for all DNA inserts including AT rich repetitive or str ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Automation of MicroC as a CDx for myeloma therapies

    SBC: Lynx Biosciences, LLC            Topic: 102

    Multiple myeloma MM is a debilitating and currently incurable hematological malignancy While the median survival has increased to years MM patients ultimately relapse and become resistant to therapy Once they reach this stage it is often a trial and error process until an effective therapy can be found Furthermore the MM bone marrow tumor microenvironment plays a significant role in ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. IMMEDIATE FIT USING INNOVATIVE TECHNOLOGY PROSTHETIC SYSTEMS

    SBC: IFIT PROSTHETICS, LLC            Topic: N

    ABSTRACT The principal business interestiFIT Prosthetics LLCwith STTR fundingcreated a new transtibial prosthetic device and demonstrated its safetycomfortand functionIn contrast to conventionally made prosthetic limbsthe iFIT prosthesis is easily fit and aligned on the residual limb in a single sessionDue to its substantial adjustability and customized inner linerthe iFIT device is a comfortable ...

    SBIR Phase II 2017 Department of Health and Human Services
  7. SBIR Phase I: Metal Additive Manufacturing Simulation on a Desktop

    SBC: SciArt            Topic: MN

    This SBIR phase I project will provide a unique computational capability to additive manufacturing (AM) designers, engineers, and technicians for making better decisions with regards to metal 3D printing. Through AM, one can fabricate complex parts that were previously impossible to manufacture. Perfecting an AM process is however non-trivial, entailing time-consuming and expensive shop-floor expe ...

    SBIR Phase I 2017 National Science Foundation
  8. SBIR Phase II: Neural Algorithms for Multimodal Sensory Analysis

    SBC: Thalchemy Corp            Topic: EW

    The broader impact/commercial potential of this project is to enable continuous sensing applications in a wide range of energy-constrained sensor-enabled devices. Without dramatic innovations in the development of ultralow power sensory processing, continuous and accurate sensing will remain a niche application limited to environments with a stable and plentiful power source and significant comput ...

    SBIR Phase II 2017 National Science Foundation
  9. Novel Continuous Esophageal Pressure Monitoring Catheter with Feeding Tube

    SBC: Rush River Research Corporation            Topic: NICHD

    PROJECT SUMMARY ABSTRACT Over US adults and children are on mechanical ventilators in intensive care units each year While major advancements in ventilator devices have improved outcomes for critically ill patients current ventilator practice is predominately based on measurements of airway pressure The more relevant pressure particularly to determine if mechanical ventilation is causi ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A Novel Strategy to Identify Substances that Improve Mitochnodrial Fitness

    SBC: CYTEGEN CORP            Topic: NIA

    Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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